51A PB1 T296R substitution enhance polymerase activity and confer a virulent phenotype to a 2009 pandemic H1N1 influenza virus in mice

作者： Yu, Zhijun; Qin, Chuan; Xia, Xianzhu; Yu, Zhijun; Qin, Chuan; Xia, Xianzhu; Yu, Zhijun; Sun, Weiyang; Zhang, Xinghai; Li, Yuanguo; Wang, Tiecheng; Wang, Hualei; Xin, Yue; Li, Xue; Zhang, Kun; Huang, Jing; Yang, Songtao; Gao, Yuwei; Xia, Xianzhu; Cheng, Kaihui; Zhang, Qianyi; Chen, Hualan; Wilker, Peter R.; Yue, Donghui; Gao, Yuwei; Xia, Xianzhu; Xia, Xianzhu; SCI

机构： Chinese Acad Med Sci, Inst Lab Anim Sci, Beijing 100021, Peoples R China; Peking Union Med Coll, Beijing 100021, Peoples R China; Acad Mil Med Sci, Mil Vet Res Inst, Key Lab Jilin Prov Zoonosis Prevent & Control, Changchun 130122, Peoples R China; Acad Mil Med Sci, Mil Vet Res Inst, Key Lab ;

来源：VIROLOGY

关键词： Influenza A virus H1N1 Mouse model Virulence

52Molecular characterization, receptor binding property, and replication in chickens and mice of H9N2 avian influenza viruses isolated from chickens, peafowls, and wild birds in eastern China

作者： Guo, Jing; Wang, Yanwen; Gao, Xinxin; Wang, Mengjing; Zhang, Hong; Liu, Wenqiang; Wang, Chao; Shen, Jinyan; Sun, Xiaohong; Wang, Wenting; Han, Xinyu; Zhang, Xiaoxuan; Hou, Zhengyang; Jin, Xinlin; Peng, Na; Li, Yubao; Li, Xuyong; Zhao, Conghui; Zhang, Yaping; Li, Jiqing; Cui, Pengfei; Chen, Hualan; Xia, Yingju; Xu, Lu; Zhang, Qianyi; He, Guimei; SCI

机构： Liaocheng Univ, Coll Agron, Liaocheng, Shandong, Peoples R China; Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, Harbin, Peoples R China; China Inst Vet Drug Control, Nat Class Swine Fever Reference Lab, Beijing, Peoples R China; East China Normal Univ, Inst Ecochongming IEC, Shanghai, Peoples R China;

来源：EMERGING MICROBES & INFECTIONS

关键词： Avian influenza virus; chicken; peafowl; wild birds

年份：2021

53A single-amino-acid mutation at position 225 in hemagglutinin attenuates H5N6 influenza virus in mice

作者： Kong, Xingtian; Chen, Hualan; Kong, Xingtian; Guan, Lizheng; Shi, Jianzhong; Kong, Huihui; Zhang, Yaping; Zeng, Xianying; Tian, Guobin; Liu, Liling; Li, Chengjun; Deng, Guohua; Chen, Hualan; Kawaoka, Yoshihiro; SCI

机构： Gansu Agr Univ, Coll Vet Med, Lanzhou, Peoples R China; Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, Harbin, Peoples R China; Univ Tokyo, Inst Med Sci, Dept Microbiol & Immunol, Div Virol, Tokyo, Japan;

来源：EMERGING MICROBES & INFECTIONS

关键词： Influenza virus; molecular basis; pathogenicity; mice

年份：2021

54Mutations of 127, 183 and 212 residues on the HA globular head affect the antigenicity, replication and pathogenicity of H9N2 avian influenza virus

作者： Fan, Menglu; Liang, Bing; Zhao, Yongzhen; Liu, Qingzheng; Tian, Miao; Zheng, Yiqing; Xia, Huizhi; Ping, Jihui; Fan, Menglu; Liang, Bing; Zhao, Yongzhen; Liu, Qingzheng; Tian, Miao; Zheng, Yiqing; Xia, Huizhi; Ping, Jihui; Zhang, Yaping; Chen, Hualan; Suzuki, Yasuo; SCI

机构： Nanjing Agr Univ, MOE Int Joint Collaborat Res Lab Anim Hlth & Food, Nanjing 210095, Peoples R China; Nanjing Agr Univ, Jiangsu Engn Lab Anim Immunol, Coll Vet Med, Nanjing 210095, Peoples R China; CAAS, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, Harbin, Peoples R China; Chubu Univ, Coll Life & Hlth Sci, Kasugai, Aichi, Japan;

来源：TRANSBOUNDARY AND EMERGING DISEASES

关键词： antigenicity; avian influenza A virus; glycosylation; pathogenicity

55SUMOylation of Matrix Protein M1 and Filamentous Morphology Collectively Contribute to the Replication and Virulence of Highly Pathogenic H5N1 Avian Influenza Viruses in Mammals

作者： Guo, Jing; Li, Xuyong; Guo, Jing; Chen, Jianing; Li, Yuanyuan; Li, Yanbing; Deng, Guohua; Shi, Jianzhong; Liu, Liling; Chen, Hualan; Li, Xuyong; SCI

机构： Liaocheng Univ, Coll Agron, Liaocheng, Shandong, Peoples R China; Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, Harbin, Peoples R China;

来源：JOURNAL OF VIROLOGY

关键词： avian influenza virus; M1; morphology; pathogenicity; SUMOylation

年份：2022

56Robustness of the Ferret Model for Influenza Risk Assessment Studies: a Cross-Laboratory Exercise

作者： Belser, Jessica A.; Lau, Eric H. Y.; Peiris, Malik; Yen, Hui-Ling; Barclay, Wendy; Barr, Ian G.; Lee, Leo Yi Yang; Subbarao, Kanta; Chen, Hualan; Yang, Huanliang; Fouchier, Ron A. M.; Herfst, Sander; Hatta, Masato; Kawaoka, Yoshihiro; Neumann, Gabriele; Lakdawala, Seema S.; Perez, Daniel R.; Russell, Charles; Webby, Richard J.; Subbarao, Kanta; Sutton, Troy C.; SCI

机构： Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA 30333 USA; Univ Hong Kong, Li Ka Shing Fac Med, Sch Publ Hlth, Hong Kong, Peoples R China; Imperial Coll, London, England; Doherty Inst, WHO Collaborating Ctr Reference & Res Influenza, VIDRL, Melbourne, Vic, Australia; Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, Harbin, Peoples R China; Erasmus MC, Dept Virosci, Rotterdam, Netherlands; Univ Wisconsin, Madison, WI USA; Univ Pittsburgh, Pittsburgh, PA USA; Univ Georgia, Athens, GA 30602 USA; St Jude Childrens Res Hosp, Dept Infect Dis, 332 N Lauderdale St, Memphis, TN 38105 USA; Univ Melbourne, Doherty Inst, Dept Microbiol & Immunol, Melbourne, Vic, Australia; Penn State Univ, University Pk, PA 16802 USA;

来源：MBIO

关键词： assay standardization; ferret model; influenza; pandemic risk assessment; transmissibility

57Specific Monoclonal Antibodies Targeting Unique HA Epitopes Block H7N9 Influenza A Viral Replication

作者： Shen, Wentao; Wang, Qian; Wang, Zhengxiang; Liu, Minxuan; Du, Yingying; Yuan, Lvfeng; Han, Lu; Xu, Shuai; Zhu, Qiyun; Smietanka, Krzysztof; Chen, Hualan; SCI

机构： Lanzhou Univ, Chinese Acad Agr Sci, Coll Vet Med, Lanzhou Vet Res Inst,State Key Lab Vet Etiol Biol, Lanzhou, Peoples R China; Natl Vet Res Inst, Dept Poultry Dis, Pulawy, Poland; Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, Harbin, Peoples R China;

来源：JOURNAL OF VIROLOGY

关键词： monoclonal antibody; hemagglutinin; prophylaxis; therapy

年份：2022

58Immune Escape Adaptive Mutations in Hemagglutinin Are Responsible for the Antigenic Drift of Eurasian Avian-Like H1N1 Swine Influenza Viruses

作者： Xu, Chengzhi; Zhang, Naixin; Yang, Yuying; Liang, Wenhua; Zhang, Yaping; Wang, Jingfei; Wu, Yunpu; Chen, Yan; Yang, Huanliang; Qiao, Chuanling; Chen, Hualan; Suzuki, Yasuo; Wu, Yunpu; SCI

机构： Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, Harbin, Peoples R China; Univ Shizuoka, Dept Med Biochem, Sch Pharmaceut Sci, Shizuoka, Japan; Liaonirg Univ Tradit Chinese Med, Shenyang, Peoples R China;

来源：JOURNAL OF VIROLOGY

关键词： antigenicity; escape mutant; HA protein; swine influenza virus

59H7N9 virus infection triggers lethal cytokine storm by activating gasdermin E-mediated pyroptosis of lung alveolar epithelial cells

作者： Wan, Xiaopeng; Li, Jiqing; Yu, Xiaofei; He, Xijun; Shi, Jianzhong; Deng, Guohua; Zeng, Xianying; Tian, Guobin; Li, Yanbing; Jiang, Yongping; Guan, Yuntao; Li, Chengjun; Chen, Hualan; Wang, Yupeng; Shao, Feng; SCI

机构： Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, Harbin 150069, Peoples R China; Natl Inst Biol Sci, Beijing 102206, Peoples R China;

来源：NATIONAL SCIENCE REVIEW

关键词： H7N9 virus; cytokine storm; gasdermin E; pyroptosis

年份：2022

60Emergence, Evolution, and Biological Characteristics of H10N4 and H10N8 Avian Influenza Viruses in Migratory Wild Birds Detected in Eastern China in 2020

作者： Wang, Yanwen; Wang, Mengjing; Zhang, Hong; Li, Yubao; Liu, Wenqiang; Shen, Jinyan; Sun, Xiaohong; Wang, Wenting; Guo, Jing; Li, Xuyong; Zhao, Conghui; Zhang, Yaping; Deng, Guohua; Cui, Pengfei; Zeng, Xianying; Li, Yanbing; Chen, Hualan; Chu, Dong; Peng, Peng; He, Guimei; SCI

机构： Liaocheng Univ, Coll Agron, Liaocheng, Shandong, Peoples R China; Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, Harbin, Peoples R China; Natl Forestry & Grassland Adm, Gen Stn Surveillance Wildlife Dis & Wildlife Born, Shenyang, Peoples R China; East China Normal Univ, Inst Ecochongming IEC, Shanghai, Peoples R China;

来源：MICROBIOLOGY SPECTRUM

关键词： avian influenza virus; wild birds; replication and transmission