1PB2-E627K and PA-T97I substitutions enhance polymerase activity and confer a virulent phenotype to an H6N1 avian influenza virus in mice

作者： Cheng, Kaihui; Yu, Zhijun; Sun, Weiyang; Xin, Yue; Huang, Jing; Zhang, Kun; Li, Xue; Yang, Songtao; Wang, Tiecheng; Zheng, Xuexing; Wang, Hualei; Qian, Jun; Gao, Yuwei; Xia, Xianzhu; Cheng, Kaihui; Yu, Zhijun; Qin, Chuan; Xia, Xianzhu; Yu, Zhijun; Qin, Chuan; Xia, Xianzhu; Zhang, Qianyi; Chen, Hualan; Chai, Hongliang; Hua, Yuping; SCI

机构： Acad Mil Med Sci, Mil Vet Res Inst, Key Lab Jilin Prov Zoonosis Prevent & Control, Changchun 130122, Peoples R China; Acad Mil Med Sci, Mil Vet Res Inst, Key Lab Jilin Prov Zoonosis Prevent & Contro;

来源：VIROLOGY

关键词： Avian influenza virus H6N1 Mice Pathogenicity

2A genome-wide CRISPR/Cas9 gene knockout screen identifies immunoglobulin superfamily DCC subclass member 4 as a key host factor that promotes influenza virus endocytosis

作者： Song, Yangming; Chen, Hualan; Song, Yangming; Huang, Haixiang; Hu, Yuzhen; Zhang, Jiwen; Li, Fang; Yin, Xin; Shi, Jianzhong; Li, Yanbing; Li, Chengjun; Zhao, Dongming; Chen, Hualan; SCI

机构： Gansu Agr Univ, Coll Vet Med, Lanzhou, Peoples R China; Chinese Acad Agr Sci, State Key Lab Vet Biotechnol, Harbin Vet Res Inst, Harbin, Peoples R China;

来源：PLOS PATHOGENS

年份：2021

3MicroRNA-200c-targeted contactin 1 facilitates the replication of influenza A virus by accelerating the degradation of MAVS

作者： Xu, Shuai; Han, Lu; Wei, Yanli; Zhang, Bo; Wang, Qian; Liu, Junwen; Liu, Minxuan; Chen, Zhaoshan; Wang, Zhengxiang; Zhu, Qiyun; Zhang, Bo; Chen, Hualan; SCI

机构： Lanzhou Univ, Chinese Acad Agr Sci, Lanzhou Vet Res Inst, Coll Anim Med,State Key Lab Vet Etiol Biol, Lanzhou, Peoples R China; Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, Harbin, Peoples R China;

来源：PLOS PATHOGENS

年份：2022

4Identification of a Highly Conserved Epitope on Avian Influenza Virus Non-Structural Protein 1 Using a Peptide Microarray

作者： Sun, Jiashan; Shi, Lin; Zheng, Shimin; Sun, Jiashan; Wang, Xiurong; Wen, Xuexia; Bao, Hongmei; Tao, Qimeng; Jiang, Yongping; Zeng, Xianying; Xu, Xiaolong; Tian, Guobin; Chen, Hualan; Sun, Jiashan; Wang, Xiurong; Wen, Xuexia; Bao, Hongmei; Tao, Qimeng; Jiang, Yongping; Zeng, Xianying; Xu, Xiaolong; Tian, Guobin; Chen, Hualan; SCI

机构： Northeast Agr Univ, Coll Vet Med, Harbin, Peoples R China; Chinese Acad Agr Sci, Harbin Vet Res Inst, Minist Agr, Anim Influenza Lab, Harbin, Peoples R China; Chinese Acad Agr Sci, Harbin Vet Res Inst, Mini;

来源：PLOS ONE

年份：2016

5Phospholipid scramblase 1 interacts with influenza A virus NP, impairing its nuclear import and thereby suppressing virus replication

作者： Luo, Weiyu; Zhang, Jie; Liang, Libin; Wang, Guangwen; Li, Qibing; Zhu, Pengyang; Zhou, Yuan; Li, Junping; Zhao, Yuhui; Sun, Nan; Huang, Shanyu; Zhou, Chenchen; Chang, Yu; Cui, Pengfei; Chen, Pucheng; Jiang, Yongping; Deng, Guohua; Bu, Zhigao; Li, Chengjun; Jiang, Li; Chen, Hualan; SCI

机构： Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, Harbin, Heilongjiang, Peoples R China; Chinese Acad Agr;

来源：PLOS PATHOGENS

年份：2018

6A broad-spectrum vaccine candidate against H5 viruses bearing different sub-clade 2.3.4.4 HA genes

作者： Zhang, Yuancheng; Cui, Pengfei; Shi, Jianzhong; Zeng, Xianying; Jiang, Yongping; Chen, Yuan; Zhang, Jie; Wang, Congcong; Wang, Yan; Tian, Guobin; Chen, Hualan; Kong, Huihui; Deng, Guohua; SCI

机构： Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Anim Dis Control & Prevent, Harbin, Peoples R China;

来源：NPJ VACCINES

年份：2024

7Limited compatibility between the RNA polymerase components of influenza virus type A and B

作者： Iwatsuki-Horimoto, Kiyoko; Muramoto, Yukiko; Kawaoka, Yoshihiro; Horimoto, Taisuke; Hatta, Yasuko; Hatta, Masato; Kawaoka, Yoshihiro; Chen, Hualan; Chen, Hualan; SCI

机构： Univ Tokyo, Inst Med Sci, Div Virol, Dept Microbiol & Immunol,Minato Ku, Tokyo 1088639, Japan; Univ Wisconsin, Sch Vet Med, Dept Pathobiol Sci, Madison, WI 53706 USA; Chinese Acad Agr Sci, Harbin Vet Res Inst, Anim Influenza Lab, Minist Agr, Harbin 150001, Peoples R China; Chinese Acad Agr Sci, Harbin Vet Res Inst, Natl Key Lab Vet Biotechnol, Harbin 150001, Peoples R China;

来源：VIRUS RESEARCH

关键词： influenza virus RNA polymerase

年份：2008

8Immunogenicity and Protective Efficacy of a Live Attenuated H5N1 Vaccine in Nonhuman Primates

作者： Fan, Shufang; Gao, Yuwei; Li, Yanbing; Shi, Jianzhong; Jiang, Yongping; Suo, Yongbing; Tong, Tiegang; Zhong, Gongxun; Song, Jiasheng; Zhang, Ying; Tian, Guobin; Guan, Yuntao; Bu, Zhigao; Chen, Hualan; Fan, Shufang; Gao, Yuwei; Li, Yanbing; Shi, Jianzhong; Jiang, Yongping; Suo, Yongbing; Tong, Tiegang; Zhong, Gongxun; Song, Jiasheng; Zhang, Ying; Tian, Guobin; Guan, Yuntao; Bu, Zhigao; Chen, Hualan; Shinya, Kyoko; Kawaoka, Yoshihiro; Li, Chris Kafai; Xu, Xiao-Ning; Kawaoka, Yoshihiro; Kawaoka, Yoshihiro; Kawaoka, Yoshihiro; SCI

机构： Chinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R China; Chinese Acad Agr Sci, Anim Influenza Lab, Minist Agr, Harbin, Peoples R Chin;

来源：PLOS PATHOGENS

年份：2009

9Human antibody 3E1 targets the HA stem region of H1N1 and H5N6 influenza A viruses

作者： Wang, Wenshuai; Zhang, Tianlong; Wang, Fang; Ding, Jianping; Wang, Wenshuai; Zhang, Tianlong; Wang, Fang; Ding, Jianping; Sun, Xiaoyu; Zhang, Hong; Sun, Bing; Li, Yanbing; Chen, Hualan; Su, Jinpeng; Ling, Zhiyang; Sun, Bing; Ding, Jianping; SCI

机构： Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Ctr Excellence Mol Cell Sci, Natl Ctr Prot Sci Shanghai,State Key Lab Mol Biol, 320 Yue Yang Rd, Shanghai 200031, Peoples R China; Univ Chinese Acad Sci, Chinese Acad Sci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China; Univ Chinese Acad Sci, C;

来源：Nature Communications

年份：2016

10Correlation between polymerase activity and pathogenicity in two duck H5N1 influenza viruses suggests that the polymerase contributes to pathogenicity

作者： Leung, Bo Wah; Brownlee, George G.; Chen, Hualan; SCI

机构： Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England; Chinese Acad Agr Sci, Harbin Vet Res Inst, Harbin, Peoples R China;

来源：VIROLOGY

关键词： H5N1 Influenza A/duck/Fujian/01/2002 Influenza A/duck/Guangxi/53/2002 RNA polymerase PA subunit PB2 subunit Replication

年份：2010