Certification of a novel matrix reference material for accurate measurements of aflatoxin M1 in milk powder

文献类型： 外文期刊

第一作者： Huang, Chun Yuan

作者： Huang, Chun Yuan;Liu, Ya Xuan;Zhou, Jian;Wang, Ming;Yang, Meng Rui;Li, Fukai;Zhang, Liyuan;Zhou, Jian;Wang, Ming;Yang, Meng Rui;Li, Fukai;Zhang, Liyuan;Liu, Hui

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关键词： Aflatoxin M1; Certified reference material; Characterization; Homogeneity; Stability; Uncertainty

期刊名称：ACCREDITATION AND QUALITY ASSURANCE （ 影响因子：0.9； 五年影响因子：0.9 ）

ISSN： 0949-1775

年卷期： 2024 年 29 卷 3 期

页码：

收录情况： SCI

摘要： In this study, two different concentrations of matrix certified reference materials (CRMs) were produced for the accurate measurement of aflatoxin M1(AFM1) in milk powder (GBW(E) 100552, GBW(E) 100553). The raw material was obtained by feeding cows with positive drugs. The homogeneity, stability and characterization of these matrix CRMs were examined by liquid chromatography tandem mass spectrometry with isotope-labeled internal standard method. The certified value for the low concentration of AFM1 in milk powder was 2.45 mu g/kg with an expanded uncertainty of 0.43 mu g/kg (coverage factor k = 2, at 95% confidence). The certified value for the high concentration of AFM1 in milk powder was 3.45 mu g/kg with an expanded uncertainty of 0.49 mu g/kg (coverage factor k = 2, at 95% confidence). In addition, the samples were evaluated in detail for homogeneity, long-term stability at - 80 degrees C for 6 months and short-term stability at 4 degrees C for 7 days. The results showed that the samples were stable and homogeneous under the above conditions.

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