Structural Derivatives of β-Asarone from Acorus calamus Linn. as Insecticide Candidates and the Insecticidal Mechanism Against Small Brown Planthopper

文献类型： 外文期刊

第一作者： Wang, Aiyu

作者： Wang, Aiyu;Zhou, Yun;Jia, Xiuwen;Zhu, Yanwei;Zhang, Yun;Xue, Chao;Shan, Chenggang;Zhao, Ming;Yang, Yuanxue;Zhang, Jianhua;Fu, Xiaochen;Shan, Chenggang;Wang, Xin;Cheng, Yinjie;Zhang, Yifei

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关键词： beta-asarone; active substructure splicing; insecticide activity; Laodelphax striatellus; MDR49

期刊名称：AGRONOMY-BASEL （ 影响因子：3.4； 五年影响因子：3.8 ）

ISSN：

年卷期： 2024 年 14 卷 10 期

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收录情况： SCI

摘要： The small brown planthopper (SBPH), Laodelphax striatellus (Fall & eacute;n) (Hemiptera: Delphacidae), is an increasing threat to Gramineae crops, posing significant risks to both the environment and food safety. beta-asarone, as a promising green alternative to chemical insecticides, possesses wide application prospects in the crop protection field. To enhance the insecticidal activity of beta-asarone, a series of derivatives were prepared through an active substructure splicing strategy, and their insecticidal activities against SBPH were evaluated. Among the 7 commercial compounds with chemical structures similar to beta-asarone and 12 structural derivatives of beta-asarone, compound 10, which incorporates the 2-chloropyridine functional group from flupyrimin, exhibited the most potent insecticidal activity against SBPH, with an 8.31-fold increase in insecticidal activity compared to beta-asarone. Furthermore, transcriptome analysis showed that among the selected genes that may play important roles in insecticidal activity, an ABC transporter gene, MDR49, was most significantly down-regulated. MDR49 was highly expressed in the 4th-instar nymphs, with the highest expression level in the fat body, midgut, and abdomen. RNA interference (RNAi) against MDR49 significantly reduced susceptibility to compound 10 in SBPH, which revealed that MDR49 may be the candidate insecticidal target of compound 10. Additionally, the insecticidal spectrum revealed that compound 10 showed excellent efficacy against Bemisia tabaci (Gennadius) (Hemiptera: Aleyrodidae) and Tetranychus cinnabarinus (Boisduval) (Acarina: Tetranychidae). This study indicates that compound 10 could be further developed as a novel eco-friendly pesticide.

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