Expression of the Ovine Gene and the Relationship Between Its Polymorphism and Feed Efficiency Traits

文献类型： 外文期刊

第一作者： Zeng, Xiwen

作者： Zeng, Xiwen;Wang, Weimin;Li, Xiaolong;Zhao, Liming;Wang, Jianghui;Xu, Dan;Cheng, Jiangbo;Li, Wenxin;Zhou, Bubo;Lin, Changchun;Yang, Xiaobin;Zhai, Rui;Ma, Zongwu;Liu, Jia;Cui, Panpan;Zhang, Xiaoxue;Wang, Weimin;Zhang, Deyin;Zhang, Yukun;Zhao, Yuan;Weng, Xiuxiu;Wu, Weiwei;Zheng, Wenxin

作者机构：

关键词： BANK1 gene; qRT-PCR; SNP; feed efficiency; Hu sheep

期刊名称：DNA AND CELL BIOLOGY （ 影响因子：3.1； 五年影响因子：3.1 ）

ISSN： 1044-5498

年卷期： 2023 年 42 卷 4 期

页码：

收录情况： SCI

摘要： In the mutton industry, feed efficiency traits have the greatest influence on the economic benefits of sheep raised in housing conditions. In this study, quantitative real-time PCR (qRT-PCR), Sanger sequencing, and KASPar methods were used to detect the expression levels of the B cell scaffold protein with ankyrin repeats 1 (BANK1) gene and the relationship between its polymorphism and feed efficiency traits in Hu sheep. The qRT-PCR results showed that the BANK1 gene was extensively expressed in 10 tissues and it was expressed at remarkably higher levels in lymph than in other tissues (p < 0.05). Then, the polymorphism locus, g.93888 A > T, was detected in intron 4 of the BANK1 gene and proved to be remarkably associated with feed efficiency traits (p < 0.05). Hence, the BANK1 gene can be used as a candidate gene for improving the feed efficiency of Hu sheep and this locus could be used as a potential molecular marker for breeding high-feed efficiency sheep in future breeding efforts.

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