The maize PLASTID TERMINAL OXIDASE (PTOX) locus controls the carotenoid content of kernels

文献类型： 外文期刊

第一作者： Nie, Yongxin

作者： Nie, Yongxin;Ding, Haiping;Du, Jiyuan;Li, Xiaohu;Li, Xinzheng;Zhao, Yajie;Zhang, Xiansheng;Zhao, Xiangyu;Zhang, Zhiming;Wang, Hui;Shi, Jian;Pan, Guangtang;Zhang, Guan;Han, Beibei;Wu, Qingyu;Liu, Lei;Zhang, Xiaocong;Liu, Changlin;Weng, Jianfeng;Li, Xinhai;Jackson, David;Li, Qin-Bao;Hunter, Charles T.;Stinard, Philip S.;Sachs, Martin M.;Arp, Jennifer;Sachs, Martin M.;Moose, Steven;Arp, Jennifer

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关键词： carotene; provitamin A; biofortification; albescent1

期刊名称：PLANT JOURNAL （ 影响因子：7.2； 五年影响因子：7.9 ）

ISSN： 0960-7412

年卷期： 2024 年 118 卷 2 期

页码：

收录情况： SCI

摘要： Carotenoids perform a broad range of important functions in humans; therefore, carotenoid biofortification of maize (Zea mays L.), one of the most highly produced cereal crops worldwide, would have a global impact on human health. PLASTID TERMINAL OXIDASE (PTOX) genes play an important role in carotenoid metabolism; however, the possible function of PTOX in carotenoid biosynthesis in maize has not yet been explored. In this study, we characterized the maize PTOX locus by forward- and reverse-genetic analyses. While most higher plant species possess a single copy of the PTOX gene, maize carries two tandemly duplicated copies. Characterization of mutants revealed that disruption of either copy resulted in a carotenoid-deficient phenotype. We identified mutations in the PTOX genes as being causal of the classic maize mutant, albescent1. Remarkably, overexpression of ZmPTOX1 significantly improved the content of carotenoids, especially beta-carotene (provitamin A), which was increased by similar to threefold, in maize kernels. Overall, our study shows that maize PTOX locus plays an important role in carotenoid biosynthesis in maize kernels and suggests that fine-tuning the expression of this gene could improve the nutritional value of cereal grains.

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