Metabolism of tributyltin and triphenyltin by Dall's porpoise hepatic microsomes

文献类型： 外文期刊

第一作者： Yang, Jian

作者： Yang, Jian;Oshima, Yuji;Sei, Ito;Miyazaki, Nobuyuki

作者机构：

关键词： tributyltin;tiphenyltin;metabolism;hepatic microsome;dall's porpoise

期刊名称：CHEMOSPHERE （ 影响因子：7.086； 五年影响因子：6.956 ）

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收录情况： SCI

摘要： The in vitro metabolism of tributyltin (TBT) and triphenyltin (TPT) by the hepatic microsomal cytochrome P-450 system enzymes of Dall's porpoises (Phocoenoides dalli) was comparatively elucidated with those enzymes of the Sprague Dawley rat in the present study. Our results suggested firstly a limited metabolic capacity for TBT and especially TPT to their metabolites in the Dall's porpoises, and documented a similar mechanism of a relatively stronger metabolic rate of TBT to its metabolites than that of TPT in the micro-some of porpoises and rat. However, the metabolic capacity to degrade both TBT and TPT were much lower in the microsome of porpoises than that in the rats.

分类号： X51

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