Effects of Lactobacillus plantarum-loaded W1/O/W2 emulsions stabilized by ultrasonically treated pea protein on DSS-induced colitis in mice
文献类型： 外文期刊
第一作者： Zhang, Chao
作者： Zhang, Chao;Zhang, Nan;Zhang, Yu;Liu, Xia;Qiu, Bin;Qi, Shasha;Li, Yonghao;Liu, Wei;Zhang, Nan;Li, Lingfei;Gao, Xueyan;Li, Yonghao
作者机构：
关键词： Pea protein; L. plantarum-loaded W1/O/W2 emulsion; DSS-induced colitis mouse model
期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.5； 五年影响因子：8.7 ）
ISSN： 0141-8130
年卷期： 2025 年 311 卷
页码：
收录情况： SCI
摘要： This study evaluates the efficacy of Lactobacillus plantarum (L. plantarum) NBRC15891 encapsulated in a W1/O/ W2 emulsion stabilized by ultrasonically treated pea protein nanoparticles (HIU-PPI-NP) for alleviating colitis. The results indicate that HIU-PPI-NP effectively preserved bacterial viability during simulated gastrointestinal digestion, with a survival rate of 72.62 %, significantly higher than that of free bacteria (0.0017 %). In vivo, the L. plantarum-loaded emulsion alleviated dextran sodium sulfate (DSS) -induced colitis in mice by improving body weight, reducing the disease activity index (DAI), and decreasing myeloperoxidase (MPO) activity in the colonic tissue. Gene expression analysis revealed reduction in inflammation markers (TNF-alpha, IL-6) and restoration of MUC2 expression. Furthermore, microbiota analysis indicated that L. plantarum-loaded emulsion altered the microbiota composition by promoting beneficial genera, such as Lachnospiraceae_NK4A136_group and Eubacterium_siraeum_group, while inhibiting the pathogenic growth of Escherichia-Shigella. Additionally, an increase in short-chain fatty acid (SCFA) concentrations was observed in mice treated with the L. plantarum-loaded emulsion. Importantly, neither free L. plantarum cells nor L. plantarum-free emulsion exhibited comparable therapeutic effects on colitis, suggesting that this emulsion system could aid in protecting L. plantarum and enhancing its efficacy. These findings underscore the potential of HIU-PPI-NP-stabilized emulsion as a novel probiotic delivery system for gut health application.
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