Lynamicin B is a Potential Pesticide by Acting as a Lepidoptera-Exclusive Chitinase Inhibitor

文献类型： 外文期刊

第一作者： Lu, Qiong

作者： Lu, Qiong;Liu, Lin;Zhou, Yong;Liu, Tian;Yang, Qing;Xu, Liping;Song, Yongxiang;Ju, Jianhua;Ju, Jianhua;Yang, Qing;Yang, Qing

作者机构：

关键词： chitinase; inhibitor; insecticide; natural enemy; integrated pest management

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：5.895； 五年影响因子：6.048 ）

ISSN： 0021-8561

年卷期： 2021 年 69 卷 47 期

页码：

收录情况： SCI

摘要： Insect group h chitinase is a promising target for designing non-target safe pesticides in that it is exclusively distributed in lepidopteran insects, over 80% of which are agricultural pests. In this work, lynamicin B was discovered to be an inhibitor of Of Chi-h, the group h chitinase from the lepidopteran pest Ostrinia furnacalis. Lynamicin B was revealed to competitively inhibit Of Chi-h with a Ki value of 8.76 mu M and does not significantly inhibit other chitinases. The co-crystal structure of lynamicin B and Of Chi-h revealed that the dichloroindolyl group of lynamicin B occupies an unexplored pocket below subsites +1 and +2 of the substrate-binding cleft, which is vital for its selectivity. Feeding experiments demonstrated that lynamicin B exhibited high insecticidal activities against other lepidopteran pests Mythimna separata and Spodoptera frugiperda besides O. furnacalis. Moreover, lynamicin B did not affect Trichogramma ostriniae, a natural enemy of O. furnacalis. This study provides a natural-derived potent pesticide for the control of lepidopteran pests, leaving its natural enemy unaffected.

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