Bioactivity Isochromenes from Cigar Tobacco-Derived Endophytic Fungus Aspergillus fumigatus

文献类型： 外文期刊

第一作者： Liu, Wen-Yu

作者： Liu, Wen-Yu;Zhang, Ping;Wang, Wei-Guang;Li, Yin-Ke;Hu, Qiu-Fen;Liu, Wen-Yu;Zhang, Ping;Kong, Guang-Hui;Su, Yu-Long;Li, Wei;Song, Xue-Ru;Gong, Da-Ping;Hu, Qiu-Fen;Zhao, Gao-Kun

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关键词： isochromenes; tobacco; endophytic fungus Aspergillus fumigatus; antibacterial activity

期刊名称：CHEMISTRY OF NATURAL COMPOUNDS （ 影响因子：0.8； 五年影响因子：0.8 ）

ISSN： 0009-3130

年卷期： 2024 年 60 卷 3 期

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收录情况： SCI

摘要： Two new isochromenes, 1-(8-methoxy-3-methyl-1H-isochromen-6-yl)propan-1-one (1) and 3-hydroxy-1-(8- methoxy-3-methyl-1H-isochromen-7-yl)propan-1-one (2), along with five known ones, (3-7) were isolated from the fermentation products of a cigar tobacco-derived endophytic fungus Aspergillus fumigatus. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were evaluated for their antibacterial activities against Pseudomonas syringae (the main pathogenic sources of tobacco angular spot disease). Compounds 1 and 2 showed activity with MIC50 values of 6.8 and 8.4 mu g/mL, respectively, whereas the MIC50 value of the positive control (agricultural streptomycin) is 2.2 mu g/mL. The efficiencies of 1 and 2 are lower than that of the positive control.

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