Low glycemic index potato biscuits alleviate physio-histological damage and gut dysbiosis in rats with type-2 diabetes mellitus induced by high-sugar and high-fat diet and streptozotocin

文献类型： 外文期刊

第一作者： Zhao, Renjie

作者： Zhao, Renjie;Li, Nan;Liu, Wei;Liu, Qiannan;Zhang, Liang;Zhao, Ruixuan;Hu, Honghai;Peng, Xingyun;Zhao, Ruixuan;Hu, Honghai

作者机构：

关键词： Type 2 diabetes; Low-glycemic index; Potato biscuits; Oat bran; Inulin; Gut microbiota

期刊名称：JOURNAL OF NUTRITIONAL BIOCHEMISTRY （ 影响因子：5.6； 五年影响因子：5.9 ）

ISSN： 0955-2863

年卷期： 2023 年 119 卷

页码：

收录情况： SCI

摘要： Type 2 diabetes mellitus (T2DM) is the most common type of diabetes globally and poses a major concern for human health. This study aimed to investigate the effects on T2DM of low-glycemic index (GI) potato biscuits with oat bran and inulin as functional additives. T2DM was induced in rats by streptozotocin (STZ) and a high-sugar and high-fat diet. The alleviation of T2DM by low-GI potato biscuits at different doses was evaluated based on the analysis of glycolipid levels, histological observations, inflammatory markers, and gut microbiota structure. Compared to wheat biscuits, low-GI potato biscuits resulted in lower postprandial blood glucose levels. After 8 weeks of intervention, fasting blood sugar levels were 16.9% lower in T2DM rats fed high-dose low-GI potato biscuits than in untreated T2DM rats. Moreover, the intervention with low-GI potato biscuits significantly alleviated T2DM-induced pathological damage, glucose and lipid metabolic disorders, and inflammation by reversing the levels of total cholesterol, triglycerides, high-density lipopro-tein cholesterol, low-density lipoprotein cholesterol, transforming growth factor -fi, interleukin-1fi, interleukin-6 and tumor necrosis factor-& alpha;. Moreover, the levels of short-chain fatty acids and gut microbiota structure in T2DM rats were significantly reversed. The abundance of beneficial bacteria (e.g., Bifidobac-terium, Lachnoclostridium, Roseburia) in the gut of T2DM rats was significantly increased whereas the abundance of Escherichia-Shigella and Desulfovibrio decreased. The present study revealed that low-GI potato biscuits alleviated damages caused by high-sugar and high-fat diet-and STZ-induced T2DM in rats, as well as reversed disturbances in the gut microbiota. Thus, low-GI potato biscuits are potentially beneficial to T2DM patients.& COPY; 2023 Elsevier Inc. All rights reserved.

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