Laburnicolamine: A Rare Penillic Acid Congener from the Nematode Cyst-Associated Fungus Laburnicola nematophila

文献类型： 外文期刊

第一作者： Wennrich, Jan-Peer

作者： Wennrich, Jan-Peer;Holzenkamp, Caren;Ebada, Sherif S.;Stadler, Marc;Wennrich, Jan-Peer;Holzenkamp, Caren;Ebada, Sherif S.;Stadler, Marc;Wennrich, Jan-Peer;Holzenkamp, Caren;Stadler, Marc;Ashrafi, Samad;Maier, Wolfgang;Ashrafi, Samad;Wang, Hao;Ibrahim, Mahmoud A. A.;Ibrahim, Mahmoud A. A.;Ebada, Sherif S.

作者机构：

关键词： Laburnicola; penillic acid; penicillin G; antimicrobial

期刊名称：CHEMISTRY & BIODIVERSITY （ 影响因子：2.3； 五年影响因子：2.5 ）

ISSN： 1612-1872

年卷期： 2024 年 21 卷 8 期

页码：

收录情况： SCI

摘要： A chemical investigation of a methanol extract derived from a solid-state rice culture of the nematode-cyst associated fungus Laburnicola nematophila K01 led to the isolation and characterization of a previously undescribed penillic acid analogue named laburnicolamine (1). The chemical structure was elucidated through comprehensive 1D and 2D NMR spectroscopic analyses in methanol-d(4) and DMSO-d(6), alongside with HR-ESI-MS spectrometry. The absolute configuration of 1 was concluded through the electronic circular dichroism (ECD) and time-dependent density functional theory-ECD (TDDFT-ECD) computations compared to its acquired spectrum. Biological assays revealed that compound 1 exhibited no significant cytotoxic, antimicrobial, or nematicidal activity.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序