Lanostane triterpenoids with anti-proliferative and PTP1B/α-glucosidase inhibitory activities from the fruiting bodies of Ganoderma calidophilum

文献类型： 外文期刊

第一作者： Yang, Li

作者： Yang, Li;Ma, Qing-Yun;Xie, Qing-Yi;Guo, Jiao-Cen;Dai, Hao-Fu;Zhao, You-Xing;Yang, Li;Ma, Qing-Yun;Xie, Qing-Yi;Guo, Jiao-Cen;Dai, Hao-Fu;Zhao, You-Xing;Zhang, Ting-Ting;Yu, Zhi-Fang;Lu, Jia-Ju

作者机构：

关键词： Ganoderma calidophilum; Lanostane triterpenoids; PTP1B; alpha-glucosidase; Anti-proliferative activity

期刊名称：PHYTOCHEMISTRY （ 影响因子：3.8； 五年影响因子：4.0 ）

ISSN： 0031-9422

年卷期： 2023 年 215 卷

页码：

收录情况： SCI

摘要： Twelve previously undescribed and four known lanostane triterpenoids were isolated from the fruiting bodies of Ganoderma calidophilum. The structures of undescribed compounds, ganodecalones H-S (1-12), were elucidated by extensive spectroscopic analysis as well as ECD and NMR calculations. Compound 4 showed significant inhibitory activity against human leukaemia cell line K562, gastric cancer cell line SGC-7901, and cervical cancer cell line HeLa with IC50 values of 13.10 +/- 0.19, 17.26 +/- 4.75, and 4.36 +/- 0.58 mu M, respectively. Compound 16 exhibited inhibitory potency against protein tyrosine phosphatase 1B (PTP1B) and alpha-glucosidase with IC50 values of 30.2 +/- 0.13 mu M and 120.6 +/- 0.14 mu M, respectively. The binding sites and interactions of 16 with PTP1B and alpha-glucosidase were revealed using molecular docking simulations.

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