Dietary fiber-derived short-chain fatty acids: A potential therapeutic target to alleviate obesity-related nonalcoholic fatty liver disease

文献类型： 外文期刊

第一作者： Zhang, Shumin

作者： Zhang, Shumin;He, Hengxun;Ma, Xi;Zhao, Jingwen;Xie, Fei;Dai, Xiaofeng;Johnston, Lee J.;Wu, Chaodong

作者机构：

关键词： dietary fiber; gut-liver axis; NAFLD; SCFAs

期刊名称：OBESITY REVIEWS （ 影响因子：9.213； 五年影响因子：12.127 ）

ISSN： 1467-7881

年卷期： 2021 年 22 卷 11 期

页码：

收录情况： SCI

摘要： Over the past several decades, increasing global prevalence of obesity-related nonalcoholic fatty liver disease (NAFLD) has been one of main challenges to human health. Recently, increasing evidence has validated connections among short chain fatty acids (SCFAs), a physiologically relevant concentration, the intestinal microbiota, and host metabolism. In this review, we summarized crosstalk between SCFAs and host metabolism in relation to NAFLD pathophysiology, focusing on recent advances. Firstly, how SCFAs are generated and absorbed under different nutritional conditions in the gut. Secondly, how SCFAs maintain gut barrier and alleviate hepatic inflammatory responses. Thirdly, how SCFAs maintain hepatic energy balance through controlling appetite and mediating the glucose homeostasis at the systemic level. Fourthly, G-protein-coupled receptors (GPRs) are widely involved in the above metabolic processes regulated by SCFAs. Overall, this review aimed to provide new insights into the prospects of SCFAs as a potential therapeutic target in management of liver diseases.

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