Xishaglaucumins A-J, New Cembranoids with Anti-Inflammatory Activities from the South China Sea Soft Coral Sarcophyton glaucum

文献类型： 外文期刊

第一作者： Li, Jin-Feng

作者： Li, Jin-Feng;Zeng, Yan-Bo;Li, Jin-Feng;Li, Wang-Sheng;Zhang, Hai-Yan;Guo, Yue-Wei;Li, Jin-Feng;Zeng, Yan-Bo;Li, Wang-Sheng;Luo, Hui;Guo, Yue-Wei

作者机构：

关键词： Sarcophyton glaucum; Cembranoids; Configuration determination; X-ray diffraction; NMR spectroscopy

期刊名称：CHINESE JOURNAL OF CHEMISTRY （ 影响因子：6.0； 五年影响因子：3.19 ）

ISSN： 1001-604X

年卷期： 2022 年 40 卷 1 期

页码：

收录情况： SCI

摘要： Ten new cembrane-type diterpenoids, namely xishaglaucumins A-J (1-10), along with ten known related ones (11-20), have been isolated from the soft coral Sarcophyton glaucum collected off the Xisha Island in the South China Sea. Their structures were elucidated by extensive spectroscopic analysis, quantum mechanical nuclear magnetic resonance (QM-NMR) methods, X-ray diffraction analysis, chemical methods and comparison with the reported data in the literature. The absolute configuration of new compounds 1, 5 and known compounds 11, 12, 16 and 20 were determined either by chemical methods or by X-ray diffraction analysis using Cu K alpha (lambda = 1.5417 angstrom). In in vitro bioassay, compound 4 exhibited inhibitory effects on lipopolysaccharide (LPS)-induced inflammatory responses in BV-2 microglial cells. [GRAPHICS]

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