Strategies to enhance production of metabolites in microbial co-culture systems

文献类型： 外文期刊

第一作者： Guo, Lichun

作者： Guo, Lichun;Xi, Bingwen;Lu, Liushen;Guo, Lichun

作者机构：

关键词： Co-cultivation; Microorganism; Natural products; Microbial interactions; Microbial consortia

期刊名称：BIORESOURCE TECHNOLOGY （ 影响因子：9.7； 五年影响因子：9.4 ）

ISSN： 0960-8524

年卷期： 2024 年 406 卷

页码：

收录情况： SCI

摘要： Increasing evidence shows that microbial synthesis plays an important role in producing high value-added products. However, microbial monoculture generally hampers metabolites production and limits scalability due to the increased metabolic burden on the host strain. In contrast, co-culture is a more flexible approach to improve the environmental adaptability and reduce the overall metabolic burden. The well-defined co-culturing microbial consortia can tap their metabolic potential to obtain yet-to-be discovered and pre-existing metabolites. This review focuses on the use of a co-culture strategy and its underlying mechanisms to enhance the production of products. Notably, the significance of comprehending the microbial interactions, diverse communication modes, genetic information, and modular co-culture involved in co-culture systems were highlighted. Furthermore, it addresses the current challenges and outlines potential future directions for microbial co-culture. This review provides better understanding the diversity and complexity of the interesting interaction and communication to advance the development of co-culture techniques.

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