Rutin reduces the pathogenicity of Streptococcus agalactiae to tilapia by inhibiting the activity of sortase A
文献类型： 外文期刊
第一作者： Dong, Jing
作者： Dong, Jing;Zhang, Lushan;Xu, Ning;Zhou, Shun;Yang, Qiuhong;Liu, Yongtao;Yang, Yibin;Ai, Xiaohui;Dong, Jing;Xu, Ning;Zhou, Shun;Yang, Qiuhong;Liu, Yongtao;Yang, Yibin;Ai, Xiaohui;Song, Yi
作者机构：
关键词： Streptococcus agalactiae; Sortase A; Rutin; Anti-virulence
期刊名称：AQUACULTURE （ 影响因子：4.242； 五年影响因子：4.723 ）
ISSN： 0044-8486
年卷期： 2021 年 530 卷
页码：
收录情况： SCI
摘要： Streptococcus agalactiae can cause multiple infections both in human and animals. Treatment failure caused by antibiotic resistance, however, limits the application of antibiotics. Drugs based on novel strategies, therefore, are needed to fight bacterial infections. Sortase A (SrtA) anchoring surface proteins to the cell wall envelope plays a critical role in Gram-positive bacterial pathogenesis, suggesting that SrtA is a promising target for developing anti-virulence drugs. In this paper, we found that rutin without anti- S. agalactiae activity could reduce adhesion of S. agalactiae to fibronectin and biofilm formation by inhibiting SrtA activity in a dose-dependent manner. Moreover, rutin decreased the adhesion and invasion of S. agalactiae to A549 cells. In vivo study demonstrated that rutin could provide a significant protection against S. agalactiae infection in tilapia. The findings in the present study indicated that rutin is a potent anti-virulence agent against S. agalactiae infections via inhibiting SrtA activity.
分类号：
- 相关文献
作者其他论文 更多>>
-
Comparative miRNAome combined with transcriptome and degradome analysis reveals a novel miRNA-mRNA regulatory network associated with starch metabolism affecting pre-harvest sprouting resistance in wheat
作者：Sun, Longqing;Qin, Dandan;Dong, Jing;Zhao, Ting;Ren, Xifeng;Zhang, Daorong
关键词：Wheat; Pre-harvest sprouting; MiRNA; Seed germination; Starch
-
Molecular mechanism of Yersinia ruckeri Flagellin C (FliC) induced intestinal inflammation in channel catfish ( Ictalurus punctatus)
作者：Yang, Yibin;He, Hao;Ai, Xiaohui;Zhu, Xia;Huang, Yucong;Yin, Fei;Xu, Jingen;Chen, Yuhua
关键词：Channel catfish; Yersinia ruckeri; Virulence; Intestinal inflammation; Molecular mechanism
-
Characteristics and functions of interleukin 21 in channel catfish (Ictalurus punctatus)
作者：He, Hao;He, Hao;Zhu, Xia;Dong, Jing;Yang, Qiuhong;Ai, Xiaohui;Yang, Yibin;Deng, Ping;Huang, Yucong;Wang, Hui
关键词：Channel catfish; IL-21; Immune response; Inflammatory factors; Gene expression
-
Population Pharmacokinetics of Enrofloxacin in Ctenopharyngodon idella Based on the Sparse Sampling Method and a Nonlinear Mixed Effect Model Following Intravenous and Oral Administration
作者：Xu, Ning;Zhang, Huan;Zhou, Shun;Liu, Yongtao;Yang, Qiuhong;Dong, Jing;Ai, Xiaohui;Xu, Ning;Zhou, Shun;Liu, Yongtao;Yang, Qiuhong;Dong, Jing;Ai, Xiaohui;Zhang, Huan;Ding, Yongzhen
关键词：bioavailability; enrofloxacin; grass carp; population pharmacokinetics
-
Identification and biological characterization of the pathogen responsible for acute haemorrhagic disease in largemouth bass
作者：Yang, Yibin;He, Hao;Yang, Qiuhong;Ai, Xiaohui;Zhu, Xia;Deng, Ping
关键词：Streptococcus iniae; Largemouth bass; Whole genome; Virulence; Drug resistance
-
Mining of co-expression genes in response to cold stress at maize (Zea mays L.) germination and sprouting stages by weighted gene co-expression networks analysis
作者：Shi, Chuangye;Sun, Liquan;Wu, Weilin;Shi, Chuangye;Dong, Jing;Zhang, Chunxiao;Jin, Fengxue;Zhou, Xiaohui;Liu, Xueyan;Li, Xiaohui
关键词：Maize; Weighted gene co-expression network; Transcriptome; Hub genes; Low temperature stress
-
Population Pharmacokinetics of Enrofloxacin in Micropterus salmoides Based on a Nonlinear Mixed Effect Model After Intravenous and Oral Administration
作者：Xu, Ning;Zhou, Shun;Dong, Jing;Li, Jiangtao;Ai, Xiaohui;Xu, Ning;Ding, Yongzhen
关键词：enrofloxacin; population pharmacokinetics; statistical approaches; largemouth bass; body weight
