Lipidome disturbances in preadipocyte differentiation associated with bisphenol A and replacement bisphenol S exposure

文献类型： 外文期刊

第一作者： Zeng, Jun

作者： Zeng, Jun;Li, Junli;Liu, Sishangyu;Yang, Zhiqiang;Zhong, Yue;Chen, Xiaomei;Li, Guiling;Li, Jia;Zeng, Jun;Li, Guiling

作者机构：

关键词： Bisphenol S; Bisphenol A; Lipidomics; Adipocyte differentiation; Insulin resistance

期刊名称：SCIENCE OF THE TOTAL ENVIRONMENT （ 影响因子：7.963； 五年影响因子：7.842 ）

ISSN： 0048-9697

年卷期： 2021 年 753 卷

页码：

收录情况： SCI

摘要： Bisphenol S (BPS) is the major substitute for the production of bisphenol A (BPA)-free products and detected in both food and environment. Although the relationship between BPA exposure and increased risk of obesity and diabetes has been noted, the potential influence of BPS is not fully understood. Herein, a non-targeted lipidomic study was performed to explore BPA/BPS exposure actions using the 3T3-L1 preadipocyte differentiation model, and revealed the comprehensive lipidome disturbance induced by either BPA or BPS exposure at different doses of 0.01, 1 and 100 mu M. BPA was more potent than BPS in disturbance of lipid metabolism. A considerable similarity of BPS exposure to BPA was discovered. The key lipid remodeling in response to exposure was found to involve the cardiolipins, phosphatidylglycerols and fatty acids metabolic pathways, providing novel clues of potential mechanism in which both BPA and BPS exposure could be associated with increased risk of insulin resistance. Our study supplies the perspective into the lipidome response to environmental stress induced by BPA/BPS, and shows that BPA-free products are not necessarily safer. Substitution of BPA by its structural analog BPS should be therefore performed with caution. (C) 2020 Elsevier B.V. All rights reserved.

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