Therapeutic Potential of Bama Pig Adipose-Derived Mesenchymal Stem Cells for the Treatment of Carbon Tetrachloride-Induced Liver Fibrosis

文献类型： 外文期刊

第一作者： Lai, Junhui

作者： Lai, Junhui;Lu, Huidi;Sun, Yuchen;Guan, Weijun;Zhang, Shuang;Wu, Xinran

作者机构：

关键词： Animal model; Carbon tetrachloride-treated mice; Hepatic differentiation

期刊名称：EXPERIMENTAL AND CLINICAL TRANSPLANTATION （ 影响因子：0.945； 五年影响因子：0.973 ）

ISSN： 1304-0855

年卷期： 2020 年 18 卷 7 期

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收录情况： SCI

摘要： Objectives: Liver fibrosis is inevitable in the healing process of liver injury. Liver fibrosis will develop into liver cirrhosis unless the damaging factors are removed. This study investigated the potential therapy of Bama pig adipose-derived mesenchymal stem cells in a carbon tetrachloride-induced liver fibrosis Institute of Cancer Research strain mice model. Materials and Methods: Adipose-derived mesenchymal stem cells were injected intravenously into the tails of mice of the Institute of Cancer Research strain that had been treated with carbon tetrachloride for 4 weeks. Survival rate, migration, and proliferation of adipose-derived mesenchymal stem cells in the liver were observed by histochemistry, fluorescent labeling, and serological detection. Results: At 1, 2, and 3 weeks after adipose-derived mesenchymal stem cell injection, liver fibrosis was significantly ameliorated. The injected adipose-derived mesenchymal stem cells had hepatic differentiation potential in vivo, and the survival rate of adipose-derived mesenchymal stem cells declined over time. Conclusions: The findings in this study confirmed that adipose-derived mesenchymal stem cells derived from the Bama pig can be used in the treatment of liver fibrosis, and the grafted adipose-derived mesenchymal stem cells can migrate, survive, and differentiate into hepatic cells in vivo.

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