文献类型： 外文期刊
第一作者： Liao, Rongqiang
作者： Liao, Rongqiang;Liu, Ying;Wu, Di;Xu, Meiling;Zheng, Xiaoyuan;Lv, Pin;Lv, Pin
作者机构：
关键词： Cyclodextrin; poly(ε -lysine); drug carrier; scutellarin
期刊名称：DRUG DELIVERY （ 影响因子：6.419； 五年影响因子：6.169 ）
ISSN： 1071-7544
年卷期： 2020 年 27 卷 1 期
页码：
收录情况： SCI
摘要： A novel beta-cyclodextrin pendant polymer (epsilon-PL-CD), composed of poly(epsilon-lysine) (epsilon-PL) main chain and glycine-beta-cyclodextrin (Gly-CD) side chains, was prepared by a simple two-step procedure. The epsilon-PL-CD was investigated as a drug carrier of hydrophobic drug scutellarin (SCU). The characterization and complexation mode of the SCU:epsilon-PL-CD were researched in both solution and solid state by means of photoluminescence spectroscopy, H-1 and 2D NMR, X-Ray powder diffraction (XRPD), thermal gravimetric analysis, Particle size and Zeta potential. The solubility test indicated that the solubilizing ability of SCU:epsilon-PL-CD was significantly improved compared with SCU:beta-CD and free SCU. Besides, in vitro cell experiment, it was found that SCU:epsilon-PL-CD has a strong inhibitory effect on the growth and invasion of tumor cells. The present study provides useful information for epsilon-PL-CD as a drug carrier material.
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