2-(2-Phenylethyl)chromone derivatives: Promising alpha-glucosidase inhibitors in agarwood from Aquilaria filaria
文献类型： 外文期刊
第一作者： Mi, Cheng-neng
作者： Mi, Cheng-neng;Yuan, Jing-zhe;Zhu, Man-man;Yang, Li;Wei, Yan-mei;Wang, Hao;Mei, Wen-li;Dai, Hao-fu;Mi, Cheng-neng;Yuan, Jing-zhe;Long, Wen-xing;Dai, Hao-fu;Mi, Cheng-neng;Yuan, Jing-zhe;Zhu, Man-man;Yang, Li;Wei, Yan-mei;Wang, Hao;Mei, Wen-li;Dai, Hao-fu
作者机构：
关键词： Aquilaria filaria; Agarwood; 2-(2-phenylethyl)chromone; alpha-Glucosidase inhibitory activity
期刊名称：PHYTOCHEMISTRY （ 影响因子：4.072； 五年影响因子：4.132 ）
ISSN： 0031-9422
年卷期： 2021 年 181 卷
页码：
收录情况： SCI
摘要： Twelve undescribed 2-(2-phenylethyl)chromone derivatives, including one pair of enantiomers, together with eleven known ones, were isolated from the EtOAc extract of agarwood originating from Aquilaria filaria. All structures were elucidated by spectroscopic (NMR, UV, IR, MS) methods and compared with reported data in literatures. Twenty-one compounds were assessed for alpha-glucosidase inhibitory activity, which showed inhibition of alpha-glucosidase with IC50 values ranging between 7.8 +/- 0.3 to 137.7 +/- 3.0 mu M (Acarbose, 743.4 +/- 3.3 mu M; Genistein, 8.3 +/- 0.1 mu M). Our results expanded the structural diversity of 2-(2-phenylethyl)chromones from agarwood, and revealed the potential of 2-(2-phenylethyl)chromones as alpha-glucosidase inhibitors.
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