Genetic and phylogenetic analysis of canine bufavirus from Anhui Province, Eastern China

文献类型： 外文期刊

第一作者： Wang, Yong

作者： Wang, Yong;Guo, Xu;Zhang, Da;Sun, Jianfei;Li, Wei;Fu, Ziteng;Jiang, Shudong;Li, Yongdong;Liu, Guangqing

作者机构：

关键词： Bufavirus; Phylogenetic analysis; Anhui Province; Canine

期刊名称：INFECTION GENETICS AND EVOLUTION （ 影响因子：3.342； 五年影响因子：3.188 ）

ISSN： 1567-1348

年卷期： 2020 年 86 卷

页码：

收录情况： SCI

摘要： Bufavirus is a novel virus associated with canine gastroenteritis. Three strains of bufavirus were first detected in dog feces collected from Anhui province in Eastern China. The near-complete genome sequences were amplified. Sequence alignment showed 98.3-99.5% homology between the three bufavirus strains and reference strains. Phylogenetic analysis showed the distributed viruses forming a cluster of close relationships. Selective pressure analysis of the VP2 region indicated that the canine bufavirus (CBuV) was mainly subject to negative selection during evolution. The negative selection site was located on the residue of B-cell epitopes, indicating minimal change to the virus's immunogenicity. Since this is the first report of CBuV circulating in Anhui Province, this study will provide further understanding of the phylogenetic and molecular characteristics of CBuV and serve as a reference for prevention and vaccine development.

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