Exploration of Serum Marker Proteins in Mice Induced by Babesia microti Infection Using a Quantitative Proteomic Approach

文献类型： 外文期刊

第一作者： Wang, Xiaoshuang

作者： Wang, Xiaoshuang;Ren, Shuguang;Masoudi, Abolfazl;Xue, Xiaomin;Li, Mengxue;Li, Hongxia;Zhang, Xiaojing;Wang, Hui;Liu, Jingze;Ren, Shuguang;Yang, Xiaohong;Yang, Xiaohong;Wang, Hui;Liu, Jingze

作者机构：

关键词： Babesia microti; Serum; Infection; Proteomic

期刊名称：PROTEIN JOURNAL （ 影响因子：2.371； 五年影响因子：1.929 ）

ISSN： 1572-3887

年卷期： 2021 年 40 卷 1 期

页码：

收录情况： SCI

摘要： Babesia microti is a protozoan that mainly parasitizes rodent and human erythrocytes. B. microti infection can result in changes in the expression levels of various proteins in the host serum. To explore the mechanism underlying the regulation of serum proteins by the host during B. microti infection, this study used a data-independent acquisition (DIA) quantitative proteomic approach to perform comprehensive quantitative proteomic analysis on the serum of B. microti-infected mice. We identified and analysed 333 serum proteins during the infectious stage and recovery stage within 30 days of infection by B. microti in mice. Through quantitative analysis, we found 57 proteins differentially expressed in the infection stage and 69 proteins differentially expressed in the recovery stage. Bioinformatics analysis revealed that these differentially expressed proteins were mainly concentrated in organelles, cell parts, and extracellular regions that are mainly involved in immune system, metabolic, and cellular processes. Additionally, the differentially expressed proteins mainly had catalytic activity. Kyoto Encyclopedia of Genes and Genome (KEGG) pathway analysis showed that many of the differentially expressed proteins participate in the complement and coagulation cascade reaction, including complement C3, complement FP, and coagulation factor XII. The results of this study can provide more information for the selection of biomarkers for the early clinical monitoring of babesiosis and help in the treatment of babesiosis.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序