文献类型： 外文期刊

第一作者： Lamichhane, Santosh

作者： Lamichhane, Santosh;Sen, Partho;Alves, Marina Amaral;Ribeiro, Henrique C.;Raunioniemi, Peppi;Oresic, Matej;Lamichhane, Santosh;Sen, Partho;Alves, Marina Amaral;Ribeiro, Henrique C.;Raunioniemi, Peppi;Oresic, Matej;Sen, Partho;Oresic, Matej;Hyotylainen, Tuulia;Oresic, Matej

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关键词： microbiome; lipidomics; metabolomics; gut; lipids

期刊名称：METABOLITES （ 影响因子：4.932； 五年影响因子：4.98 ）

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年卷期： 2021 年 11 卷 1 期

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收录情况： SCI

摘要： Various studies aiming to elucidate the role of the gut microbiome-metabolome co-axis in health and disease have primarily focused on water-soluble polar metabolites, whilst non-polar microbial lipids have received less attention. The concept of microbiota-dependent lipid biotransformation is over a century old. However, only recently, several studies have shown how microbial lipids alter intestinal and circulating lipid concentrations in the host, thus impacting human lipid homeostasis. There is emerging evidence that gut microbial communities play a particularly significant role in the regulation of host cholesterol and sphingolipid homeostasis. Here, we review and discuss recent research focusing on microbe-host-lipid co-metabolism. We also discuss the interplay of human gut microbiota and molecular lipids entering host systemic circulation, and its role in health and disease.

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