Toxocara "omics" and the promises it holds for medicine and veterinary medicine

文献类型： 外文期刊

第一作者： Zheng, Wen-Bin

作者： Zheng, Wen-Bin;Liu, Guo-Hua;Zheng, Wen-Bin;Zou, Yang;Zhu, Xing-Quan;Zhu, Xing-Quan

作者机构：

期刊名称：TOXOCARA AND TOXOCARIASIS （ 影响因子：3.87； 五年影响因子：6.821 ）

ISSN： 0065-308X

年卷期： 2020 年 109 卷

页码：

收录情况： SCI

摘要： Toxocariasis is one of the most neglected worldwide zoonoses that is caused by larval nematode parasites of the genus Toxocara, Toxocara canis, and to a lesser extent, Toxocara cati, whose migration mechanism is still largely unknown. Fortunately, some advanced tools have been employed, such as genomics, transcriptomics, and proteomics, to better understand the molecular biology and regulatory mechanisms of Toxocara. Using genomics and transcriptomics, we can identify a large number of genes that participate in the development of Toxocara and the interaction of parasites and their hosts and can predict the functions of unknown genes by comparing them with other relevant species. Using proteomics, we can identify somatic proteins and excretory and secretory (ES) proteins that perform specific biological functions in tissue degradation, pathogen invasion, immune evasion or modulation. These "omics" techniques also can contribute enormously to the development of new drugs, vaccines and diagnostic tools for toxocariasis. In a word, by utilizing "omics", we can better understand the Toxocara and toxocariasis. In this review, we summarized the representative achievements in Toxocara and the interaction between Toxocara spp. and their hosts based on expressed sequence tags (ESTs), microarray gene expression, next-generation sequencing (NGS) technologies and liquid chromatography-tandem mass spectrometry (LC-MS/MS), hoping to better understand the molecular biology of Toxocara, and contribute to new progress in the application areas of new drugs, vaccines and diagnostic tool for toxocariasis in the future.

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