Effects of long-term consumption of polysaccharides from the fruit of Lycium barbarum on host's health

文献类型： 外文期刊

第一作者： Ding, Yu

作者： Ding, Yu;Chen, Dan;Chen, Guijie;Zeng, Xiaoxiong;Yan, Yamei;Mi, Jia;Lu, Lu;Cao, Youlong;Ran, Linwu

作者机构：

关键词： Wolfberry Polysaccharides; Immunomodulation; Antioxidation; Gut microbiota; Short-chain fatty acids; IgA

期刊名称：FOOD RESEARCH INTERNATIONAL （ 影响因子：6.475； 五年影响因子：6.508 ）

ISSN： 0963-9969

年卷期： 2021 年 139 卷

页码：

收录情况： SCI

摘要： Polysaccharides from the fruit of Lycium barbarum (LBPs) are functional molecules with diverse biological functions in vivo and in vitro. This study investigated the long-term consumption of LBPs on host's health in BALB/c mice. Six-week-old male mice (n = 10 each group) were fed either a normal control (NC) diet or supplemented with 200 mg/kg (body weight)/d of LBPs for 14 weeks. Compared with the NC diet, the LBPs diet enhanced the expression of mucin 2 and Claudin5, improved the intestinal barrier morphologically, moreover, promoted the growth of Lactobacillus and strongly increased the production of short-chain fatty acids and IgA (p < 0.05). Feeding LBPs increased the levels of superoxide dismutase and reduced glutathione in the serum, liver and spleen while decreased the levels of alanine aminotransferase and lysozyme in serum and spleen. Besides, the LBPs diet increased the expression of cytokines including tumor necrosis factor alpha and interleukin-6 and related mRNA but decreased the level of lysozyme. To sum up, chronic intake of LBPs in BALB/c mice improved the oxidation resistance, changed the immune status especially promoted the intestinal immunity. These results may have important implications for LBPs as functional food supplement and for realizing the potential value of LBPs for host's health.

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