Determination of Pharmacokinetic and Pharmacokinetic-Pharmacodynamic Parameters of Doxycycline against Edwardsiella ictaluri in Yellow Catfish (Pelteobagrus fulvidraco)

文献类型： 外文期刊

第一作者： Xu, Ning

作者： Xu, Ning;Ai, Xiaohui;Xu, Ning;Li, Miao;Lin, Zhoumeng;Xu, Ning;Ai, Xiaohui;Ai, Xiaohui

作者机构：

关键词： doxycycline; pharmacokinetics; pharmacokinetic-pharmacodynamic (PK/PD) parameters; Edwardsiella ictaluri; yellow catfish

期刊名称：ANTIBIOTICS-BASEL （ 影响因子：3.893； ）

ISSN： 2079-6382

年卷期： 2021 年 10 卷 3 期

页码：

收录情况： SCI

摘要： This study aimed to examine the pharmacokinetics of doxycycline (DC) in yellow catfish (Pelteobagrus fulvidraco) and to calculate related pharmacokinetic-pharmacodynamic (PK/PD) parameters of DC against Edwardsiella ictaluri. The minimum inhibitory concentration of DC against E. ictaluri was determined to be 500 mu g/L. As the increase of oral dose from 10 to 40 mg/kg, the area under the concentration vs. time curve from 0 to 96 h (AUC(0-96)) values were considerably increased in gill, kidney, muscle and skin, and plasma, except in liver. C-max values exhibited a similar dose-dependent increase trend in plasma and tissues except in liver, but other PK parameters had no apparent dose-dependence. The PK/PD parameter of the ratio of AUC(0-96) to minimum inhibitory concentration (AUC(0-96h)/MIC) was markedly increased in plasma and tissues dose-dependently except in liver, but %T > MIC values were increased only moderately at some dose groups. After receiving the same dose with disparate time intervals from 96 to 12 h, the AUC(0-96h)/MIC was distinctly increased in plasma and tissues, but the %T > MIC had a decreasing trend. When administering 20 mg/kg with a time interval of 96 h, the AUC(0-96h)/MIC values were consistently >173.03 h and the %T > MIC values were above 99.47% in plasma and all tissues. These results suggest that administration of DC at 20 mg/kg every 96 h is a preferable regimen in yellow catfish.

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