Palladium-catalyzed Ugi-type reaction of 2-iodoanilines with isocyanides and carboxylic acids affording N-acyl anthranilamides dagger
文献类型： 外文期刊
第一作者： Yao, Tuanli
作者： Yao, Tuanli;Wang, Bo;Ren, Beige;Qin, Xiangyang;Li, Tao
作者机构：
期刊名称：CHEMICAL COMMUNICATIONS （ 影响因子：5.996； 五年影响因子：5.818 ）
ISSN： 1359-7345
年卷期： 2021 年 57 卷 35 期
页码：
收录情况： SCI
摘要： The first palladium-catalyzed Ugi-type multicomponent reaction for the synthesis of N-acyl anthranilamides from isocyanides, 2-iodoanilines and carboxylic acids has been developed. This method provides expeditious and highly efficient access to structurally diverse N-acyl anthranilamides from readily available starting materials with good functional group compatibility. The utility of this method has been demonstrated by the late stage functionalization of two commercial drugs: Flurbiprofen and Loxoprofen.
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