2-Hydroxypropyl-beta-cyclodextrin encapsulates dimethyl disulfide producing a controlled release formulation

文献类型： 外文期刊

第一作者： Hao, Baoqiang

作者： Hao, Baoqiang;Ren, Lirui;Huang, Bin;Tang, Xiujun;Cheng, Hongyan;Yan, Dongdong;Li, Yuan;Cao, Aocheng;Ouyang, Canbin;Wang, Qiuxia

作者机构：

关键词： HP-beta-CD; Inclusion complex; Fumigant; Controlled release; Control efficiency

期刊名称：SCIENCE OF THE TOTAL ENVIRONMENT （ 影响因子：6.551； 五年影响因子：6.419 ）

ISSN： 0048-9697

年卷期： 2021 年 773 卷

页码：

收录情况： SCI

摘要： Dimethyl disulfide (DMDS), a soil fumigant, is an effective, broad-spectrum compound that often replaces bromomethane (MB) in the prevention and treatment of soil-borne diseases. However, the disadvantages of DMDS include toxicity, volatility, pungent odor, risk of human exposure, and environmental pollution. Cyclodextrin (CD) has been widely used as a carrier of chemicals in many industries due to its functional advantages and safety. In this study, a DMDS-controlled release formulation was developed by encapsulating DMDS in the cavity of 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD). This formulation reduced DMDS usage and production costs. Orthogonal experimental design, Fourier transforminfrared (FT-IR), Scanning electronmicroscopy (SEM), Thermal gravity analysis (TGA) characterization, efficacy comparison, safety, and other aspects of the evaluation showed that under the best preparation conditions, the encapsulation rate was 81.49%. The efficacy of DMDS@HP-beta-CD was similar to unformulated DMDS. The efficacy duration of the formulation was about two times longer than DMDS, and itwas safer to use. This study reveals a cyclodextrin-DMDS formulationwith reduced toxicity, longer duration, environmental safety and sustainability. (C) 2021 Published by Elsevier B.V.

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