Green tea polyphenols supplementation alters immunometabolism and oxidative stress in dairy cows with hyperketonemia

文献类型： 外文期刊

第一作者： Ma, Yanfen

作者： Ma, Yanfen;Zhang, Guijie;Ma, Yanfen;Feng, Ying;Song, Liwen;Bao, Hua;Zhang, Chunhua;Yi, Jing;Feng, Ying;Li, Muyang;Zhao, Lei;Dai, Hongyu;Liang, Yusheng;Liang, Yusheng

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关键词： Green tea polyphenol; Hyperketonemia; Peripartal period; Dairy cow

期刊名称：ANIMAL NUTRITION （ 影响因子：4.492； ）

ISSN： 2405-6383

年卷期： 2021 年 7 卷 1 期

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收录情况： SCI

摘要： Peripartal cows often experience negative energy balance, and are therefore prone to suffering from metabolic diseases such as hyperketonemia, which causes financial losses in dairy farms. This study aimed to investigate the effect of green tea polyphenol (GTP) supplementation during the periparturient period on production performance, oxidative stress and immunometabolism in dairy cows with hyperketonemia. One hundred Holstein cows were assigned to GTP (0.2 g/kg DM; n = 50) or control (without GTP; n = 50) group based on body weight, previous milk yield, and parity on d 15 before expected parturition. Subsequently, 10 cows with hyperketonemia were selected from each group, according to blood beta-hydroxybutyric acid (BHBA) concentration between 1.2 and 2.9 mmol/L from 2 to 3 d postpartum. All cows were fed a close-up diet and a lactation diet with or without GTP supply from 15 d prepartum until 30 d postpartum. Milk and blood samples were obtained from 20 cows selected with hyperketonemia on 10, 20, and 30 d postpartum. Compared with control cows, greater milk yield and lower somatic cell count were observed in GTP cows. The GTP group had lower concentrations of BHBA, free fatty acids, cholesterol, triglyceride, reactive oxygen species, malondialdehyde, and hydrogen peroxide, greater concentrations of glucose, lower activities of aspartate aminotransferase, alanine aminotransferase, and glutamyl transpeptidase, alongside greater activities of superoxide dismutase, glutathione peroxidase, and total antioxidant capacity. Additionally, GTP supplementation up-regulated concentrations of interleukin-6 and interleukin-10, but down-regulated concentrations of tumor necrosis factor-alpha, interleukin-1 beta, interleukin-2, interleukin-8, and interferon-gamma in plasma. Greater concentrations of plasma immunoglobulin G were also detected in the GTP group. Overall, the data suggested that GTP supplementation from 15 d prepartum to 30 d postpartum improved the milk yield and health status in cows with hyperketonemia during early lactation. (C) 2021, Chinese Association of Animal Science and Veterinary Medicine. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.

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