Chemical Components and Their α-Glucosidase Inhibitory Activity from the Leaves of Ficus carica Linn.

文献类型： 外文期刊

第一作者： Guo, Mengjia

作者： Guo, Mengjia;Zhou, Bo;Zhao, Xinman;Tao, Ling;Shen, Xiangchun;Zhang, Nenling;Guo, Mengjia;Zhou, Bo;Zhao, Xinman;Tao, Ling;Shen, Xiangchun;Zhang, Nenling;Guo, Mengjia;Zhou, Bo;Zhao, Xinman;Tao, Ling;Shen, Xiangchun;Zhang, Nenling;Fu, Manqin

作者机构：

关键词： Ficus carica Linn.; coumarin; alpha-glucosidase inhibitor; enzyme kinetics

期刊名称：RECORDS OF NATURAL PRODUCTS （ 影响因子：1.9； 五年影响因子：1.8 ）

ISSN： 1307-6167

年卷期： 2024 年 18 卷 1 期

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收录情况： SCI

摘要： Nineteen compounds were purified from leaves of Ficus carica Linn. using various separation techniques such as recrystallization, column chromatography filled with silica gel, Sephadex LH-20, and MCI, and semi-preparative HPLC. By analysis of NMR, MS, and data comparison with those reported from literatures, their structures were identified as umbelliferone (1), psoralen (2), furopinnarin (3), 6,7-furano-hydrocoumaric acid (4), (E)-3-[5-(6-hydroxy) benzofuranyl] propenoic acid (5), (E)-3-(6-hydroxy-4-methoxy-5-benzofuranyl) propenoic acid (6), nodakenetin (7), oxypeucedanin hydrate (8), dihydrofurocoumarin (9), (E)-4-hydroxy-3,3,5-trimethy1-4-(3-oxobu-1-en-1-yl)-cyclohexan-1-one (10), dehydrovomifoliol (11), 4,5-dihydroblumenol A (12), blumenol A (13), 5-hydroxy-4',7-dimethoxyisoflavone (14), cajanin (15), loliolide (16), indole-3-carboxaldehyde (17), 1H-indole-3-carboxylic acid (18), vitamin E quinone (19). Their alpha- glucosidase inhibitory activities were evaluated by IC50 values. Compounds 15 and 19 showed obvious alpha- glucosidase inhibitory activity with IC(50 )of 71.1 +/- 1.56 mu M and 49.3 mu M +/- 1.21, respectively, and by the kinetics of enzymatic reaction, the inhibition type by which compound 15 acting against alpha-glucosidase was inferred as anticompetitive. Moreover, preliminary structure-activity relationship was recapticulated from the tested compounds.

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