Panax quinquefolius Polysaccharides Ameliorate Antibiotic-Associated Diarrhoea Induced by Lincomycin Hydrochloride in Rats via the MAPK Signaling Pathways

文献类型： 外文期刊

第一作者： Ren, Duo-duo

作者： Ren, Duo-duo;Li, Shan-shan;Lin, Hong-mei;Xia, Yun-shi;Bo, Pan-pan;Mu, Rui;Sun, Yin-shi;Ren, Duo-duo;Xia, Yun-shi;Li, Zhi-man;Bo, Pan-pan;Mu, Rui;Zhao, Li-juan;Sun, Yin-shi;Li, Shan-shan

作者机构：

期刊名称：JOURNAL OF IMMUNOLOGY RESEARCH （ 影响因子：4.493； 五年影响因子：5.601 ）

ISSN： 2314-8861

年卷期： 2022 年 2022 卷

页码：

收录情况： SCI

摘要： American ginseng (Panax quinquefolius L.) is an herbal medicine with polysaccharides as its important active ingredient. The purpose of this research was to identify the effects of the polysaccharides of P. quinquefolius (WQP) on rats with antibiotic-associated diarrhoea (AAD) induced by lincomycin hydrochloride. WQP was primarily composed of galacturonic acid, glucose, galactose, and arabinose. The yield, total sugar content, uronic acid content, and protein content were 6.71%, 85.2%, 31.9%, and 2.1%, respectively. WQP reduced the infiltration of inflammatory cells into the ileum and colon, reduced the IL-1 beta, IL-6, IL-17A, and TNF-alpha levels, increased the levels of IL-4 and IL-10 in colon tissues, improved the production of acetate and propionate, regulated the gut microbiota diversity and composition, improved the relative richness of Lactobacillus and Bacteroides, and reduced the relative richness of Blautia and Coprococcus. The results indicated that WQP can enhance the recovery of the intestinal structure in rats, reduce inflammatory cytokine levels, improve short-chain fatty acid (SCFA) levels, promote recovery of the gut microbiota and intestinal mucosal barrier, and alleviate antibiotic-related side effects such as diarrhoea and microbiota dysbiosis caused by lincomycin hydrochloride. We found that WQP can protect the intestinal barrier by increasing Occludin and Claudin-1 expression. In addition, WQP inhibited the MAPK inflammatory signaling pathway to improve the inflammatory status. This study provides a foundation for the treatment of natural polysaccharides to reduce antibiotic-related side effects.

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