Ginseng-DF ameliorates intestinal mucosal barrier injury and enhances immunity in immunosuppressed mice by regulating MAPK/NF-κB signaling pathways
文献类型： 外文期刊
第一作者： Sha, Ji-yue
作者： Sha, Ji-yue;Liu, Zheng-bo;Lu, Yu-shun;Qu, Di;Sun, Yin-shi;Chen, Ke-Cheng;Li, Wei;Liu, Shuang;Ma, Jian-kai
作者机构：
关键词： Ginseng-DF; CTX; Immunosuppression; Intestinal mucosal barrier injury; MAPK/NF-kappa B signaling pathway
期刊名称：EUROPEAN JOURNAL OF NUTRITION （ 影响因子：5.0； 五年影响因子：5.2 ）
ISSN： 1436-6207
年卷期： 2024 年
页码：
收录情况： SCI
摘要： PurposeDietary fiber (DF) has a good application prospect in effectively restoring the integrity of the intestinal mucosal barrier. Ginseng-DF has good physicochemical properties and physiological activity and shows positive effects in enhancing immunity. The aim of this study was to investigate the protective effect of Ginseng-DF on intestinal mucosal barrier injury induced by cyclophosphamide (CTX) in immunosuppressed mice and its possible mechanism.MethodsThe effects of Gginseng-DF on immune function in mice were studied by delayed-type hypersensitivy, lymphocyte proliferation assay and NK cytotoxicity assay, the T lymphocyte differentiation and intestinal barrier integrity were analyzed by flow cytometry and western blot.ResultsGinseng-DF (2.5% and 5%) could attenuate the inhibition of DTH response by CTX, promote the transformation and proliferation of lymphocytes, and stimulate NK effector cell activity. At the same time, Ginseng-DF could restore the proportion of CD4+/CD8+ T lymphocytes induced by CTX to different extents, improved spleen tissue damage, promoted the secretion of immunoglobulin IgG, and enhanced body immunity. More importantly, Ginseng-DF could up-regulate the contents of TNF-alpha, IFN-gamma, IL-6 and IL-1 beta in serum and intestine of immunosuppressed mice to maintain the balance between Th1/Th2 cytokines, and improve the permeability of intestinal mucosal barrier. Meanwhile, Ginseng-DF could reduce intestinal epithelial cell apoptosis and improve intestinal adaptive immunity in CTX-induced immunosuppressed mice by regulating MAPK/NF-kappa B signaling pathway.ConclusionGinseng-DF can be used as a safe dietary supplement to enhance body immunity and reduce intestinal mucosal injury caused by CTX.
分类号：
- 相关文献
作者其他论文 更多>>
-
The Biosynthesis of Astaxanthin Esters in Schizochytrium sp. is Mediated by a Bifunctional Diacylglycerol Acyltransferase
作者：Liu, Peng-Yang;Wu, Jun-Jie;Li, Gang;Lin, Chu-Bin;Jiang, Shan;Liu, Shuang;Wan, Xia;Lin, Chu-Bin;Liu, Shuang;Wan, Xia
关键词：astaxanthin ester; docosahexaenoic acid; lipiddroplet; acyltransferase
-
Genome-wide association study reveals the genetic basis of cold tolerance in soybean
作者：Wang, Zhiyu;Gao, Yaning;Shao, Ming;Yin, Kaiyi;Pu, Yixiang;Cheng, Hao;Yu, Deyue;Huang, Fang;Wang, Jiao;Li, Wei;Zhang, Hengyou
关键词：Soybean; Genome-wide association study; Germination; Cold tolerance
-
Whole-Genome Identification and Characterization of the DKK Gene Family and Its Transcription Profiles: An Analysis of the Chinese Soft-Shell Turtle (Pelodiscus sinensis)
作者：Wang, Yongchang;Zhu, Junxian;Chen, Chen;Ji, Liqin;Hong, Xiaoyou;Liu, Xiaoli;Chen, Haigang;Wei, Chengqing;Zhu, Xinping;Li, Wei;Wang, Yongchang;Zhang, Junjie
关键词：DKK gene family; Pelodiscus sinensis; expression analyses; sex differentiation
-
Identification and characterization of Streptococcus iniae from farmed American Bullfrogs (Aquarana catesbeiana)
作者：Sun, Jingyang;Li, Hua;Lin, Han;Chen, Kesong;Qin, Zhendong;Jiang, Biao;Li, Wei;Su, Youlu;Huang, Yanhua;Liu, Chun;Wang, Qing;Wang, Qing;Huang, Yanhua;Liu, Chun
关键词：Identification; Characterization; Streptococcus iniae; American Bullfrog
-
Cd Activation Mechanisms of High-Enriched Rapeseed (Brassica Napus L.) in Rhizosphere Soil
作者：Tian, Xiaoqin;Yang, Tingting;Li, Zhuo;Wu, Xiaoli;Li, Haojie;Tian, Xiaoqin;Li, Zhuo;Wu, Xiaoli;Tian, Xiaoqin;Li, Zhuo;Wu, Xiaoli;Liu, Dan;Liu, Yonghong;Li, Wei
关键词：Cadmium; Brassica napus; Root exudates; Bioaccumulation; Transportation
-
Characterization of Key Odorants in Lushan Yunwu Tea in Response to Intercropping with Flowering Cherry
作者：Gao, Yinxiang;Lei, Zhiyong;Yao, Liping;Liu, Wenxin;Liu, Yanan;Huang, Jigang;Liu, Shuang;Liu, Jiaxin;Chen, Yan;Sun, Yongming
关键词：Lushan Yunwu tea; flowering cherry; volatile compounds; key aroma compounds; HS-SPME/GC-MS
-
Ginsenoside Rg5 Activates the LKB1/AMPK/mTOR Signaling Pathway and Modifies the Gut Microbiota to Alleviate Nonalcoholic Fatty Liver Disease Induced by a High-Fat Diet
作者：Shi, Yingying;Sun, Qiang;Zhang, Hao;Sun, Yinshi;Shi, Yingying;Chen, Jianbo;Qu, Di;Sun, Qiang;Yu, Yang;Zhang, Hao;Liu, Zhengbo;Sha, Jiyue;Sun, Yinshi
关键词：ginsenoside Rg(5); nonalcoholic fatty liver disease; fecal microbiota transplantation; LKB1/AMPK/mTOR signaling pathway
