Carboxymethyl polysaccharides from Poria cocos (Schw.) wolf: Structure, immunomodulatory, anti-inflammatory, tumor cell proliferation inhibition and antioxidant activity

文献类型： 外文期刊

第一作者： Liu, Haocheng

作者： Liu, Haocheng;Yang, Jiguo;Tang, Yuqian;Liu, Haocheng;Yang, Jiguo;Xia, Xiaole;Tang, Yuqian;Lin, Jinxin

作者机构：

关键词： Carboxymethyl-pachymaran; Degree of substitution (DS); Molecular weight (mw); Immunomodulation; Anti-inflammatory; Structure-activity relationship

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.5； 五年影响因子：8.7 ）

ISSN： 0141-8130

年卷期： 2025 年 299 卷

页码：

收录情况： SCI

摘要： This study comprehensively explores the relationship between the structure of carboxymethyl-pachymaran (CMP) and its diverse biological activities, including immunomodulation, anti-inflammatory effects, tumor cell proliferation inhibition, and antioxidant activity. By adjusting preparation parameters, highly purified CMP samples with varying degrees of substitution (DS) and molecular weights (Mw) were successfully obtained. The results indicate that CMP, composed primarily of (3-D-glucan, exhibits different levels of activity depending on its structural characteristics. In terms of immunomodulation, CMP with medium Mw demonstrates the strongest activity, while CMP with a high DS promotes nitric oxide (NO) synthesis most effectively, and a moderate DS supports optimal tumor necrosis factor-alpha (TNF-alpha) synthesis. For anti-inflammatory activity, CMP with a moderate DS effectively inhibits NO production, while a low DS is most effective against TNF-alpha inhibition. Larger Mw consistently enhances the inhibitory effects on NO and TNF-alpha synthesis. Dectin-1 is identified as one of the receptors mediating CMP's immunomodulatory effects. Furthermore, CMP with a moderate DS and high Mw exhibit superior performance in inhibiting HepG-2 cell proliferation and scavenging DPPH free radicals, respectively. This study enriches understanding of (3-glucan's structure-activity relationship and lays a theoretical foundation for its medical and healthcare applications.

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