Gut microbiota mediates the protective effects of dietary beta-hydroxy-beta-methylbutyrate (HMB) against obesity induced by high-fat diets

文献类型： 外文期刊

第一作者： Duan, Yehui

作者： Duan, Yehui;Zhong, Yinzhao;Wang, Wenlong;Guo, Qiuping;Li, Yuying;Han, Hui;Gao, Jing;Xu, Kang;Li, Tiejun;Yin, Yulong;Li, Fengna;Yin, Jie;Kong, Xiangfeng;Zhong, Yinzhao;Zheng, Changbing;Song, Bo;Yin, Yulong;Xiao, Hao;Li, Fengna

作者机构：

关键词： insulin resistance; propionic acid; gut microbiota transplantation; lipid metabolism

期刊名称：FASEB JOURNAL （ 影响因子：5.191； 五年影响因子：5.955 ）

ISSN： 0892-6638

年卷期： 2019 年 33 卷 9 期

页码：

收录情况： SCI

摘要： Obesity increases the risk of developing insulin resistance and diabetes and is a major public health concern. Our previous study shows that dietary beta-hydroxy-beta-methylbutyrate (HMB) improves lipid metabolism in a pig model. However, it remains unclear whether HMB blocks obesity through gut microbiota. In this study, we found that HMB reduced body weight, alleviated the whitening of brown adipose tissue, and improved insulin resistance in mice fed a high-fat diet (HFD). High-throughput pyrosequencing of the 16S rRNA demonstrated that HMB administration significantly reversed the gut microbiota dysbiosis in HFD-fed mice, including the diversity of gut microbiota and relative abundances of Bacteroidetes and Firmicutes. Moreover, microbiota transplantation from HMB-treated mice attenuated HFD-induced lipid metabolic disorders. Furthermore, HFD-fed mice showed lower short-chain fatty acids, whereas administration of HMB increased the propionic acid production. Correlation analysis identified a significant correlation between propionic acid production and the relative Bacteroidetes abundance. Sodium propionate treatment also attenuated HFD-induced lipid metabolic disorders. Collectively, our results indicated that HMB might be used as a probiotic agent to reverse HFD-induced obesity, and the potential mechanism was associated with reprogramming gut microbiota and metabolism, especially Bacteroidetes-mediated propionic acid production. In future studies, more efforts should be made to confirm and expand the beneficial effects of HMB to human models.-Duan, Y., Zhong, Y., Xiao, H., Zheng, C., Song, B., Wang, W., Guo, Q., Li, Y., Han, H., Gao, J., Xu, K., Li, T., Yin, Y., Li, F., Yin, J., Kong, X. Gut microbiota mediates the protective effects of dietary beta-hydroxy-beta-methylbutyrate (HMB) against obesity induced by high-fat diets.

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