文献类型： 外文期刊
第一作者： Yuan, Chao
作者： Yuan, Chao;Zhang, Ying-Bo;Yang, Hong-Xia;Li, Gang;Guo, Yu-Hua;Fan, Lin
作者机构：
期刊名称：RSC ADVANCES （ 影响因子：3.361； 五年影响因子：3.39 ）
ISSN：
年卷期： 2019 年 9 卷 47 期
页码：
收录情况： SCI
摘要： Four new alpha-pyrones, hypotiens A-D (1-4), were isolated from a fungal endophyte, Hypoxylon investiens J2, harbored in the medicinal plant Blumea balsamifera. Their structures were determined through detailed HRMS and NMR spectroscopic data. Compounds 1-4 are new alpha-pyrone derivatives containing an unusual dimethyl substitution in the highly unsaturated side chain. Their plausible biosynthetic pathway was discussed. Biological assay indicated that compounds 1-4 showed no antimicrobial, quorum sensing inhibitory, and cytotoxic activities. The specific side chain in alpha-pyrone derivatives 1-4 might be responsible for the weak pharmacological activities.
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