G3BP1 inhibits RNA virus replication by positively regulating RIG-I-mediated cellular antiviral response

文献类型： 外文期刊

第一作者： Yang, Wenping

作者： Yang, Wenping;Ru, Yi;Ren, Jingjing;Bai, Juncui;Wei, Junshu;Fu, Shaozu;Liu, Xiangtao;Li, Dan;Zheng, Haixue;Yang, Wenping;Ru, Yi;Ren, Jingjing;Bai, Juncui;Wei, Junshu;Fu, Shaozu;Liu, Xiangtao;Li, Dan;Zheng, Haixue

作者机构：

期刊名称：CELL DEATH & DISEASE （ 影响因子：8.469； 五年影响因子：8.713 ）

ISSN： 2041-4889

年卷期： 2019 年 10 卷

页码：

收录情况： SCI

摘要： Retinoic acid-inducible gene I (RIG-I) is a pattern recognition receptor and is involved in the innate immune response against RNA viruses infection. Here, we demonstrate that the Ras-GTPase-activating protein SH3-domain-binding protein 1 (G3BP1) serves as a positive regulator of the RIG-I-mediated signaling pathway. G3BP1-deficient cells inhibited RNA virus-triggered induction of downstream antiviral genes. Furthermore, we found that G3BP1 inhibited the replication of Sendai virus and vesicular stomatitis virus, indicating a positive regulation of G3BP1 to cellular antiviral responses. Mechanistically, G3BP1 formed a complex with RNF125 and RIG-I, leading to decreased RNF125 via its auto-ubiquitination; thus, promoting expression of RIG-I. Overall, the results suggest a novel mechanism for G3BP1 in the positive regulation of antiviral signaling mediated by RIG-I.

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