Identification of Metabolites of 2,2 ',4,5,5 '-Pentachlorodiphenyl in Mice

文献类型： 外文期刊

第一作者： Wang Shuai

作者： Wang Shuai;Qiao Yi-Piao;Huang Xuan-Yun;Huang Dong-Mei;Tian Liang-Liang;Fang Chang-Ling;Ye Hong-Li;Shi Yong-Fu;Wang Shuai;Qiao Yi-Piao;Wang Shuai;Li Xue-Hui

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关键词： Polychlorinated biphenyls; Hydroxylated; Methyl sulfonated; Methoxylated; Metabolites; Identification; Gas chromatography-tandem mass spectrometry

期刊名称：CHINESE JOURNAL OF ANALYTICAL CHEMISTRY （ 影响因子：1.134； 五年影响因子：0.909 ）

ISSN： 0253-3820

年卷期： 2019 年 47 卷 12 期

页码：

收录情况： SCI

摘要： In this study, metabolites of 2,2', 4,5,5'-pentachlorodiphenyl (PCB101) in mice were identified. Kunming mice were exposed to PCB101 by intraperitoneal injection, and gas chromatographytandem mass spectrometry (GC-MS/MS) was adopted for metabolites identification. It was confirmed that 5 kinds of compounds including 2 hydroxylated-PCB101, 2 methyl sulfonated-PCB101 and 1 methoxylated-PCB101 were metabolized. The hydroxylated metabolites were identified as 3-OH-PCB101 and 4-OH-PCB101 mainly in the stomach, intestines, gonads, liver and blood of mice. Hydroxylation might occur in the 2,5-dichlorinated ring, via formation of an 3,4-arene oxide that subsequently rearranged to a hydroxyl group by epoxide opening, or by direct insertion of a hydroxyl group in non-chlorinated substitution site. Methyl sulfonated metabolites were identified as 3-MeSO2-PCB101 and 4-MeSO2-PCB101 mainly in the stomach, intestines, kidneys, gonads, liver and lungs of mice, methyl sulfonation might also involve the formation of 3,4-epoxides, and then underwent the mercapturic acid pathway. Methoxylated metabolite was identified as 4-MeO-PCB101 mainly in the intestines, kidneys, lungs, muscles, spleen and brain of mice, simultaneously. In this study, it was basically confirmed that PCB101 could be biotransformed into three types of metabolites in mice at least, and methoxylated metabolite was confirmed in mice for the first time, which was of great scientific significance for further study on the persistence, toxicity effects and risk assessment of PCB metabolites in organisms.

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