Genome-Wide Association Analysis Reveals Key Genes Responsible for Egg Production of Lion Head Goose

文献类型： 外文期刊

第一作者： Zhao, Qiqi

作者： Zhao, Qiqi;Zhang, Xinheng;Xu, Zhouyi;Li, Hongxin;Lin, Wencheng;Xie, Qingmei;Zhao, Qiqi;Zhang, Xinheng;Xu, Zhouyi;Li, Hongxin;Lin, Wencheng;Xie, Qingmei;Zhao, Qiqi;Zhang, Xinheng;Xu, Zhouyi;Li, Hongxin;Lin, Wencheng;Xie, Qingmei;Chen, Junpeng;Lin, Zhenping

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关键词： lion head goose; genome wide association study; egg production; candidate genes; quantitative real-time polymerase chain reaction

期刊名称：FRONTIERS IN GENETICS （ 影响因子：4.599； 五年影响因子：4.888 ）

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年卷期： 2020 年 10 卷

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收录情况： SCI

摘要： The lion head goose is one of the most important agricultural resources in China; however, its breeding process is relatively slow. In the present study, a genome-wide association study was performed for the genetic selection of egg production characters in lion head geese. We detected 30 single-nucleotide polymorphisms located in or near 30 genes that might be associated with egg production character, and quantitative real-time polymerase chain reaction was used to verify their expression level in lion head geese. The results showed that the expression levels of CRTC1 (encoding CREB-regulated transcription coactivator 1), FAAH2 (encoding fatty acid amide hydrolase 2), GPC3 (encoding glypican 3), and SERPINC1 (encoding serpin family C member 1) in high egg production population were significantly lower than those in the low egg production populations (*P < 0.05). The expression levels of CLPB (encoding caseinolytic peptidase B protein homolog), GNA12 (encoding guanine nucleotide-binding protein subunit alpha-12), and ZMAT5 (encoding zinc finger, matrin type 5) in the high egg production population were significantly higher than those in the low egg production populations (*P < 0.05). The expression of BMP4 (encoding bone morphogenetic protein 4), FRMPD3 (encoding FERM and PDZ domain containing 3), LIF (encoding leukemia inhibitory factor), and NFYC (encoding nuclear transcription factor Y subunit gamma) in the high egg production population were very significantly lower than those in the low egg production population (**P < 0.01). Our findings provide an insight into the economic traits of lion head goose. These candidate genes might be valuable for future breeding improvement.

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