Inhibition of Haemophilus parasuis by berberine and proteomic studies of its mechanism of action
文献类型： 外文期刊
第一作者： Hao, Changqi
作者： Hao, Changqi;Hua, Xin;Jia, Yue;Yang, Qin;Zhang, Wanjiang;Li, Gang;Liu, Siguo;Hao, Changqi;Hua, Xin;Jia, Yue
作者机构：
关键词： Haemophilus parasuis; Berberine; Proteomics; Virulence factor; Bacteriostatic activity; Antibacterial mechanism
期刊名称：RESEARCH IN VETERINARY SCIENCE （ 影响因子：2.534； 五年影响因子：2.382 ）
ISSN： 0034-5288
年卷期： 2021 年 138 卷
页码：
收录情况： SCI
摘要： Haemophilus parasuis is the main agent of Gla center dot sser's disease, which causes substantial losses in pig production. However, the pathogenic mechanism and virulence factors of H. parasuis have not been fully determined. In this study, berberine is shown to have a good therapeutic effect in vivo against H. parasuis; the minimal inhibitory concentration (MIC) in vitro was 2 mu g/mL. Berberine inhibited H. parasuis adhesion to and invasion of PK-15 pig kidney cells. Proteomics studies of H. parasuis after berberine treatment identified a total of 97 differentiallyexpressed proteins; 35 upregulated and 62 downregulated. Bioinformatics analysis showed that berberine may inhibit the growth of H. parasuis by affecting outer membrane proteins, transferrins, and energy metabolism. This study provides a basis for the development of new antibacterial agents.
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