Response of the critically endangered Przewalski's gazelle (Procapra przewalskii) to selenium deprived environment

文献类型： 外文期刊

第一作者： Shen, Xiaoyun

作者： Shen, Xiaoyun;Huo, Bin;Li, Yuanfeng;Song, Chunjie;Wu, Ting;He, Jian;Shen, Xiaoyun;Shen, Xiaoyun

作者机构： Southwest Univ Sci & Technol, Sch Life Sci & Engn, 59 Middle Sect Qinglong Ave, Mianyang 621010, Sichuan, Peoples R China;Xinjiang Acad Agr & Reclamat Sci, State Key Lab Sheep Genet Improvement & Hlth Prod, Shihezi 832000, Xinjiang, Peoples R China;Southwest China, World Bank Poverty Alleviat Project Off Guizhou, Guiyang 550004, Peoples R China

关键词： P; przewalskii; Omics techniques; Selenium-deprived environment; Response mechanism; The Qinghai-Tibetan Plateau

期刊名称：JOURNAL OF PROTEOMICS （ 2020影响因子：4.044； 五年影响因子：4.02 ）

ISSN： 1874-3919

年卷期： 2021 年 241 卷

页码：

收录情况： SCI

摘要： Selenium (Se) is an essential mineral nutrient for animals. Se deprivation can lead to many disorders and even death. This study investigated the response of Przewalski's gazelle (P. przewalskii) to Se-deprived environment. We found that Se deprivation in soil and forage not only influenced the mineral contents of the blood and hair in P. przewalskii, but also severely disrupted their blood parameters. We identified significant changes in the abundance of 146 proteins and 25 metabolites (P < 0.05) in serum, including the selenoproteins L8IG93 (glutathione peroxidase) and F4YD09 (Cu/Zn superoxide dismutase). Furthermore, the major known proteins and metabolites associated with the Se stress response in P. przewalskii were Cu/Zn superoxide dismutase, the vitamin K-dependent protein C, the C4b-binding protein alpha chain, complement component C7, lipase linoleic acid, peptidase D, thymidine, pseudo-uridine, L-phenylalanine, L-glutamine, PGA1, and 15-deoxy-delta-12,14PGJ2. The main signaling pathways involved included complement and coagulation cascades, metabolic pathways, and stress granule formation. Our results indicate that the intake of Se-deficient forage elicited an oxidative stress response in P. przewalskii. These findings provide insights into the response mechanisms of this threatened gazelle to Se stress, and enable the development of conservation strategies to protect populations on the QinghaiTibetan Plateau. Significance: This study is the first to point out the presence of oxidative stress in P. przewalskii in seleniumdeficient areas through proteomics and metabolomics studies. These findings should prove helpful for conservation efforts aimed at P. przewalskii populations and maintenance of the integrity of their ecological environment.

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