Newcastle disease virus infection remodels plasma phospholipid metabolism in chickens

文献类型： 外文期刊

第一作者： Dai, Jun

作者： Dai, Jun;Qiu, Xusheng;Feng, Yiyi;Hou, Yuechi;Sun, Yingjie;Liao, Yingjie;Tan, Lei;Song, Cuiping;Liu, Weiwei;Ding, Chan;Dai, Jun;Cui, Xinyuan;Shen, Yongyi;Ding, Chan

作者机构：

期刊名称：ISCIENCE （ 影响因子：5.8； 五年影响因子：5.8 ）

ISSN：

年卷期： 2024 年 27 卷 2 期

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收录情况： SCI

摘要： Newcastle disease is a global problem that causes huge economic losses and threatens the health and welfare of poultry. Despite the knowledge gained on the metabolic impact of NDV on cells, the extent to which infection modifies the plasma metabolic network in chickens remains unknown. Herein, we performed targeted metabolomic and lipidomic to create a plasma metabolic network map during NDV infection. Meanwhile, we used single -cell RNA sequencing to explore the heterogeneity of lung tissue cells in response to NDV infection in vivo. The results showed that NDV remodeled the plasma phospholipid metabolism network. NDV preferentially targets infected blood endothelial cells, antigen -presenting cells, fibroblasts, and neutrophils in lung tissue. Importantly, NDV may directly regulate ribosome protein transcription to facilitate efficient viral protein translation. In conclusion, NDV infection remodels the plasma phospholipid metabolism network in chickens. This work provides valuable insights to further understand the pathogenesis of NDV.

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