Deciphering the effective substances of mangrove plant Acanthus ilicifolius Linn. against liver injury

文献类型： 外文期刊

第一作者： Zhao, Qing

作者： Zhao, Qing;Song, Shu-Yue;Zheng, Yao-Yao;Zhang, Meng-Qi;Ren, Xia;Zhang, Ya-Hui;Fu, Xiu-Mei;Li, Xin;Wang, Chang-Yun;Zhao, Qing;Song, Shu-Yue;Zheng, Yao-Yao;Ren, Xia;Zhang, Ya-Hui;Fu, Xiu-Mei;Li, Xin;Wang, Chang-Yun;Zhao, Qing;Fang, Han;Zhang, Meng-Qi

作者机构：

关键词： Acanthus ilicifolius; effective substances; anti-liver injury; anti-inflammatory, anti-oxidation

期刊名称：NATURAL PRODUCT RESEARCH （ 影响因子：1.6； 五年影响因子：2.0 ）

ISSN： 1478-6419

年卷期： 2025 年

页码：

收录情况： SCI

摘要： The mangrove plant Acanthus ilicifolius Linn. has been recorded to treat liver injury diseases, but its active ingredients are unclear. In the present study, chemical compounds in the ethanol extract of A. ilicifolius were isolated, and their anti-liver injury, anti-inflammatory and anti-oxidant activities were evaluated to decipher the effective substances. In total, 42 compounds (1-42) were obtained, including two new naphthalene compounds (1-2). Moreover, the anti-liver injury, anti-inflammatory and anti-oxidant activities of compounds were evaluated. In CCl4-induced HepG2 cellular model, compound 33 showed significant anti-liver injury activity at 50, 25, 12.5 and 6.25 mu M, while 1, 9, 13-16, 33 showed significant activity at 50 and 25 mu M. Overall, naphthalenes (1-2), phenylethanoid glycosides (12-16), alkaloid (3), flavonoid (9) and lignin (33) could be the main effective substances in A. ilicifolius against liver injury.

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