文献类型： 外文期刊
第一作者： Ran, Hong-Ling
作者： Ran, Hong-Ling;Guan, Ya-Li;Huang, Sheng-Zhuo;Wang, Hao;Yang, Li;Yu, Miao;Gai, Cui-Juan;Duan, Rui-Jun;Dai, Hao-Fu;Mei, Wen-Li
作者机构：
关键词： Strophanthus divaricatus; Aromadendrane; Sesquiterpenoid; Cytotoxicity
期刊名称：PHYTOCHEMISTRY LETTERS （ 影响因子：1.873； 五年影响因子：1.875 ）
ISSN： 1874-3900
年卷期： 2021 年 46 卷
页码：
收录情况： SCI
摘要： Three new aromadendrane-type sesquiterpenoids (1-3) and five known compounds (4-8) were isolated from the stems of Strophanthus divaricatus. Their structures were determined by spectroscopic methods including HR-ESIMS, 1D and 2D NMR. The absolute configurations of 1-3 was determined by comparison of the experimental and computed ECD spectra. Neridienone A (6) exhibited significant cytotoxicity against human cancer cell lines BEL7402, SGC-7901, K562, A549, and HeLa with IC50 values of 3.30 +/- 0.01, 2.25 +/- 0.01, 2.02 +/- 0.03, 1.55 +/- 0.01, 4.73 +/- 0.07 isM, respectively.
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