gga-miR-200b-3p promotes avian leukosis virus subgroup J replication via targeting dual-specificity phosphatase 1

文献类型： 外文期刊

第一作者： Pang, Yanling

作者： Pang, Yanling;Yan, Yiming;Zhang, Xinheng;Chen, Feng;Luo, Qingbin;Xie, Qingmei;Lin, Wencheng;Zhang, Xinheng;Chen, Feng;Luo, Qingbin;Xie, Qingmei;Lin, Wencheng;Zhang, Xinheng;Chen, Feng;Luo, Qingbin;Xie, Qingmei;Lin, Wencheng

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关键词： gga-miR-200b-3p; ALV-J; DUSP1

期刊名称：VETERINARY MICROBIOLOGY （ 影响因子：3.246； 五年影响因子：3.565 ）

ISSN： 0378-1135

年卷期： 2022 年 264 卷

页码：

收录情况： SCI

摘要： MicroRNAs (miRNAs) involved host-virus interaction, affecting the replication or pathogenesis of several viruses. Although avian leukosis virus subgroup J (ALV-J) has been one of the most studied avian viruses, the effects of various host miRNAs on ALV-J infection and its underlying molecular mechanisms are still unclear. Here, we reported that gga-miR-200b-3p acts as a positive host factor enhancing ALV-J replication. We found that ggamiR-200b-3p was increased in response to ALV-J infection in host cells, and that gga-miR-200b-3p effectively enhanced ALV-J replication via targeting host protein dual-specificity phosphatase 1 (DUSP1). Collectively, these findings highlight a crucial role of gga-miR-200b-3p in ALV-J replication.

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