Formulation and stability of silkworm pupae oil microemulsion

文献类型： 外文期刊

第一作者： Yan, Cheng-Hai

作者： Yan, Cheng-Hai;Zhang, Dan;Wu, Ji-Long;Yang, Xue-Jun;Nian, Ji-Yao;Xun, Xiao-Meng;Wu, Fu-An;Wang, Jun;Wu, Fu-An;Wang, Jun

作者机构：

关键词： Silkworm pupae oil; Microemulsion; Pseudo-ternary phase diagram; Stability; Antioxidant activity

期刊名称：SUSTAINABLE CHEMISTRY AND PHARMACY （ 影响因子：5.464； 五年影响因子：5.599 ）

ISSN：

年卷期： 2022 年 27 卷

页码：

收录情况： SCI

摘要： Because of the instability, perishable odor and peculiar smell, a microemulsion system was designed to safely and effectively supply alpha-linolenic acid from silkworm pupae oil. Microemulsion-loaded silkworm pupae oil was prepared from isoamyl acetate, castor oil polyoxyethylene ether 35 (EL-35), ethanol and water. The optimal microemulsion formulation was a 4% composite oil phase (silkworm pupae oil: isoamyl acetate, 1:2), 16% composite surfactant (EL35: ethanol, 2:1) and 80% water, with uniformly dispersed spherical particles with diameters of 16.25 nm. The color of the microemulsion was transparent and had no peculiar smell. The investigation results of environmental stress show that the transmittance is 86%-99%, and there is no significant difference from the control group (p > 0.05). Compared with silkworm pupae oil, the total antioxidant capacity of the microemulsion was increased by 7.70 times. Microemulsionloaded silkworm pupae oil exhibited good physical and antioxidation stability. This work provides a feasible new scheme for ensuring the nutritional and health functions of silkworm pupae oil and supplying alpha-linolenic acid safely and effectively.

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