GWAS and WGCNA uncover hub genes controlling salt tolerance in maize (Zea mays L.) seedlings

文献类型： 外文期刊

第一作者： Ma, Langlang

作者： Ma, Langlang;Zhang, Minyan;Chen, Jie;Qing, Chunyan;He, Shijiang;Zou, Chaoying;Yuan, Guangsheng;Yang, Cong;Peng, Hua;Pan, Guangtang;Lubberstedt, Thomas;Shen, Yaou;Ma, Langlang;Zhang, Minyan;Chen, Jie;Qing, Chunyan;He, Shijiang;Zou, Chaoying;Yuan, Guangsheng;Yang, Cong;Peng, Hua;Pan, Guangtang;Lubberstedt, Thomas;Shen, Yaou;Ma, Langlang;Zhang, Minyan;Chen, Jie;Qing, Chunyan;He, Shijiang;Zou, Chaoying;Yuan, Guangsheng;Yang, Cong;Peng, Hua;Pan, Guangtang;Lubberstedt, Thomas;Shen, Yaou;Ma, Langlang;Zhang, Minyan;Chen, Jie;Qing, Chunyan;He, Shijiang;Zou, Chaoying;Yuan, Guangsheng;Yang, Cong;Peng, Hua;Pan, Guangtang;Lubberstedt, Thomas;Shen, Yaou

作者机构：

期刊名称：THEORETICAL AND APPLIED GENETICS （ 影响因子：5.699； 五年影响因子：5.565 ）

ISSN： 0040-5752

年卷期： 2021 年 134 卷 10 期

页码：

收录情况： SCI

摘要： Keymessage Two hub genesGRMZM2G075104andGRMZM2G333183involved in salt tolerance were identified by GWAS and WGCNA. Furthermore, they were verified to affect salt tolerance by candidate gene association analysis. Salt stress influences maize growth and development. To decode the genetic basis and hub genes controlling salt tolerance is a meaningful exploration for cultivating salt-tolerant maize varieties. Herein, we used an association panel consisting of 305 lines to identify the genetic loci responsible for Na+- and K+-related traits in maize seedlings. Under the salt stress, seven significant single nucleotide polymorphisms were identified using a genome-wide association study, and 120 genes were obtained by scanning the linkage disequilibrium regions of these loci. According to the transcriptome data of the above 120 genes under salinity treatment, we conducted a weighted gene co-expression network analysis. Combined the gene annotations, two SNaC/SKC (shoot Na+ content/shoot K+ content)-associated genes GRMZM2G075104 and GRMZM2G333183 were finally identified as the hub genes involved in salt tolerance. Subsequently, these two genes were verified to affect salt tolerance of maize seedlings by candidate gene association analysis. Haplotypes TTGTCCG-CT and CTT were determined as favorable/salt-tolerance haplotypes for GRMZM2G075104 and GRMZM2G333183, respectively. These findings provide novel insights into genetic architectures underlying maize salt tolerance and contribute to the cultivation of salt-tolerant varieties in maize.

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