One new lignan and one new fluorenone from Dendrobium nobile Lindl

文献类型： 外文期刊

第一作者： Cao, Xue

作者： Cao, Xue;Yang, Li;Dai, Hao-Fu;Wei, Yan-Mei;Huang, Sheng-Zhuo;Wang, Hao;Cai, Cai-Hong;Mei, Wen-Li;Chen, Hui-Qin;Cao, Xue;Yang, Li;Dai, Hao-Fu;Wei, Yan-Mei;Huang, Sheng-Zhuo;Wang, Hao;Cai, Cai-Hong;Mei, Wen-Li;Chen, Hui-Qin;Cao, Xue;Wang, Ling

作者机构：

关键词： Dendrobium nobile Lindl; alpha-Glucosidase; Lignan; Fluorenone

期刊名称：PHYTOCHEMISTRY LETTERS （ 影响因子：1.679； 五年影响因子：1.861 ）

ISSN： 1874-3900

年卷期： 2021 年 44 卷

页码：

收录情况： SCI

摘要： Two new compounds, dendronobilate (1) and 4-O-demethyl-nobilone (2), together with one known fluorenone were isolated from the aerial parts of Dendrobium nobile Lindl. Their structures were characterized by detailed analysis of 1D and 2D NMR spectra, HRESIMS and ECD spectra. Compounds 1-3 showed significant alpha-glucosidase inhibitory activity with IC50 values of 27.46 +/- 3.14, 4.52 +/- 0.33, and 10.78 +/- 2.05 mu M, respectively, which were superior to the acarbose (745.9 +/- 3.3 mu M). The binding interactions of 1 and 2 with alpha-glucosidase were investigated using molecular docking simulations. In addition, compound 2 exhibited potent inhibitory effect on NO production in LPS activated RAW264.7 cells with the IC50 value of 35.40 +/- 1.77 mu M without cytotoxicity observed.

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