Bisphenol F induces liver-gut alteration in zebrafish

文献类型： 外文期刊

第一作者： Wang, Hui

作者： Wang, Hui;Mu, Xiyan;Qiu, Jing;Qi, Suzhen;Wang, Hui;Mu, Xiyan;Yuan, Lilai;Li, Yingren;Mu, Xiyan

作者机构：

关键词： Bisphenol F; Liver -gut alteration; Hepatic metabolism; Intestinal microbiota; Zebra fish

期刊名称：SCIENCE OF THE TOTAL ENVIRONMENT （ 影响因子：10.753； 五年影响因子：10.237 ）

ISSN： 0048-9697

年卷期： 2022 年 851 卷

页码：

收录情况： SCI

摘要： The unease of consumers with bisphenol A has led to the increased industrial usage of bisphenol F (BPF), which is a new hazard to environmental health. Here, zebrafish were exposed to three BPF concentrations (0.5, 5, and 50 mu g/L) from the embryonic stage for 180 days. Results showed that zebrafish body length and weight decreased and hepatosomatic index values increased, even at environmentally relevant concentration. Histological analysis iden-tified the occurrence of hepatic fibrosis and steatosis in 5 and 50 mu g/L groups, which indicated the liver injury caused by BPF. Based on the untargeted metabolomics results, a dose-dependent variation in the effects of BPF on liver metab-olism was found, and amino acids, purines and one carbon metabolism were the main affected processes in the 0.5, 5, and 50 mu g/L treatments, respectively. At the same time, BPF induced a shift in intestinal microbiome composition, in-cluding decreased abundance of Erysipelotrichaceae, Rhodobacteraceae and Gemmobacter. In addition, the correlation analysis suggested an association between gut microbiome changes and affected hepatic metabolites after BPF expo -sure. These findings indicate that a liver-gut alteration is induced by long-term BPF exposure.

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