Emerging insights into macrophage extracellular traps in bacterial infections

文献类型： 外文期刊

第一作者： Baz, Ahmed Adel

作者： Baz, Ahmed Adel;Hao, Huafang;Lan, Shimei;Li, Zhangcheng;Liu, Shuang;Jin, Xiangrui;Chen, Shengli;Chu, Yuefeng;Baz, Ahmed Adel;Hao, Huafang;Lan, Shimei;Li, Zhangcheng;Liu, Shuang;Jin, Xiangrui;Chen, Shengli;Chu, Yuefeng;Baz, Ahmed Adel;Hao, Huafang;Lan, Shimei;Li, Zhangcheng;Liu, Shuang;Jin, Xiangrui;Chen, Shengli;Chu, Yuefeng;Baz, Ahmed Adel

作者机构：

关键词： bacterial infection; evasion; macrophage extracellular traps; macrophages

期刊名称：FASEB JOURNAL （ 影响因子：4.4； 五年影响因子：4.7 ）

ISSN： 0892-6638

年卷期： 2024 年 38 卷 13 期

页码：

收录情况： SCI

摘要： Macrophages possess a diverse range of well-defined capabilities and roles as phagocytes, encompassing the regulation of inflammation, facilitation of wound healing, maintenance of tissue homeostasis, and serving as a crucial element in the innate immune response against microbial pathogens. The emergence of extracellular traps is a novel strategy of defense that has been observed in several types of innate immune cells. In response to infection, macrophages are stimulated and produce macrophage extracellular traps (METs), which take the form of net-like structures, filled with strands of DNA and adorned with histones and other cellular proteins. METs not only capture and eliminate microorganisms but also play a role in the development of certain diseases such as inflammation and autoimmune disorders. The primary objective of this study is to examine the latest advancements in METs for tackling bacterial infections. We also delve into the current knowledge and tactics utilized by bacteria to elude or endure the effects of METs. Through this investigation, we hope to shed light on the intricate interactions between bacteria and the host's immune system, particularly in the context of microbicidal effector mechanisms of METs. The continued exploration of METs and their impact on host defense against various pathogens opens up new avenues for understanding and potentially manipulating the immune system's response to infections. Macrophage extracellular traps (METs) are represent an intriguing defense mechanism within the immune system. These structures consist of cellular DNA, histones, and various proteins, which serve to entrap and kill pathogens, preventing their dissemination. While METs play a crucial role in combating bacterial infections, certain bacteria can produce enzymes that degrade the DNA in METs and employ tactics to prevent MET formation altogether. Created with .image

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